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Sodium-coupled neutral amino acid transporter 3
go.drugbank.com/bio_entities/BE0000285TargetTransporterHumansSymporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). … The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827).
Polypeptides: Sodium-coupled neutral amino acid transporter 3Sodium channel protein type 4 subunit alpha
go.drugbank.com/bio_entities/BE0002083TargetTransporterHumansNavs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:12766226, PubMed:15318338, PubMed:16890191, PubMed:17898326
Polypeptides: Sodium channel protein type 4 subunit alphaSynonyms: Sodium channel protein type IV subunit alpha, Sodium channel protein skeletal muscle subunit alphaSodium/potassium-transporting ATPase subunit beta-2
go.drugbank.com/bio_entities/BE0005018TransporterTargetHumansThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-2Synonyms: Sodium/potassium-dependent ATPase subunit beta-2Calcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0000553TargetHumansPossibly induces sleep when activated by melatonin and through melatonin receptor MTNR1A-dependent dissociation of G-beta and G-gamma subunits, leading to increased sensitivity to Ca(2+) and reduced synaptic … It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane.
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1Mitogen-activated protein kinase kinase kinase 9
go.drugbank.com/bio_entities/BE0004386TargetHumansOnce activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. … The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors.
Polypeptides: Mitogen-activated protein kinase kinase kinase 9Mitogen-activated protein kinase kinase kinase 2
go.drugbank.com/bio_entities/BE0004745TargetHumansRegulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics
Polypeptides: Mitogen-activated protein kinase kinase kinase 2Calcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0004784TargetMousePotassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). … In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map.
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1Mitogen-activated protein kinase kinase kinase 20
go.drugbank.com/bio_entities/BE0005595TargetHumansActivates JNK through phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7, and MAP kinase p38 gamma (MAPK12) via phosphorylation of MAP2K3/MKK3 and MAP2K6/MKK6 (PubMed:11836244, PubMed:12220515). … Stress-activated component of a protein kinase signal transduction cascade that promotes programmed cell death in response to various stress, such as ribosomal stress, osmotic shock and ionizing radiation
Polypeptides: Mitogen-activated protein kinase kinase kinase 20Synonyms: Leucine zipper- and sterile alpha motif-containing kinase, Sterile alpha motif- and leucine zipper-containing kinase AZKMitogen-activated protein kinase kinase kinase 3
go.drugbank.com/bio_entities/BE0009467TargetHumansMediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators
Polypeptides: Mitogen-activated protein kinase kinase kinase 3Mitogen-activated protein kinase kinase kinase 6
go.drugbank.com/bio_entities/BE0009469TargetHumansActivates the JNK, but not ERK or p38 kinase pathways
Polypeptides: Mitogen-activated protein kinase kinase kinase 6