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Mycophenolic Acid Metabolism Pathway (old)
smpdb.ca/view/SMP0000652Drug metabolismMycophenolic Acid (MPA) is an immunosuppressive agent that acts as a noncompetitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). … only) and CES-2 (in the liver and intestine).
Tranexamic Acid Action Pathway (New)
smpdb.ca/view/SMP0124487Drug actionPlasmin is unable to be formed form plasminogen, and therefore, dissolution of the fibrin clot is prevented. … Tranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site.
Mefenamic Acid NSAID Action Pathway
smpdb.ca/view/SMP0124586Drug actionMefenamic acid is an NSAID used to treat mild to moderate pain for no more than a week, and primary dysmenorrhea. It has analgesic, anti-inflammatory, and antipyretic properties. … Mefenamic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionSalicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. … Salicylic acid inhibits the action of COX-1 and COX-2 on the endoplasmic reticulum membrane. This reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2).
Tiaprofenic Acid Action Pathway (New)
smpdb.ca/view/SMP0124607Drug actionTiaprofenic acid possess anti-inflammatory, analgesic and antipyretic activity. … Tiaprofenic acid is a nonsteroidal anti-inflammatory (NSAID) used to manage inflammation and analgesia associated with rheumatoid arthritis and osteoarthritis.
Drugs: Glutathione · Dinoprostone · Calcium · Tiaprofenic acid · Mesoheme · Prostaglandin G2 +1 moreMycophenolic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174716MetabolicMetabolites of Mycophenolic acid are predicted with biotransformer.
Fatty Acid Elongation in Mitochondria
smpdb.ca/view/SMP0000054MetabolicIn liver and kidney fatty acid elongation operates best in the presence of both NADH and NADPH, whereas in heart and skeletal muscle, only NADH is required. … There are 3 major processes that modify palmitic acid: elongation, desaturation and hydroxylation.
3-Hydroxyisobutyric Acid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000521Diseaseacid. … This enzyme converts 2-methyl-3-oxopropanoate, CoA and water into propanoyl-CoA, using NAD+ as an oxidizing agent, and producing a hydrogen ion and hydrogencarbonate as byproducts.
Enzymes: Branched-chain-amino-acid aminotransferase, cytosolic, Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrialAcetylsalicylic Acid Action Pathway (New)
smpdb.ca/view/SMP0124628Drug actionAspirin (acetylsalicylic acid) is an NSAID used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. … COX-2 is an inducible enzyme, and during inflammation, it is responsible for prostaglandin synthesis.
Drugs: Glutathione · Dinoprostone · Acetylsalicylic acid · Calcium · Mesoheme · Prostaglandin G2 +1 moreNalidixic acid Predicted Metabolism Pathway
smpdb.ca/view/SMP0174549MetabolicMetabolites of Nalidixic acid are predicted with biotransformer.