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Hyperornithinemia with Gyrate Atrophy (HOGA)
smpdb.ca/view/SMP0125630DiseaseHyperornithinemia with gyrate atrophy (HOGA), also known as gyrate atrophy of the choroid and retina, OAT deficiency, ornithine aminotransferase deficiency, ornithine keto acid aminotransferase deficiency) is an autosomal recessive disor...
Drugs: Pyridoxal phosphate · Ademetionine · Arginine · Aspartic acid · Ornithine · Adenosine phosphate +21 moreEnzymes: Nitric oxide synthase, brainImmunometabolism Pathway (Viral Activation)
smpdb.ca/view/SMP0125488DiseaseThe NF-kB protein then goes to nucleus and activates expression of nitric oxide synthase (iNOS) which generates nitric oxide (NO). … Higher nitric oxide (NO) levels lead to blood vessel dilation and reduced blood pressure, which in its most extreme form, can be a major problem in sepsis.
Enzymes: Nitric oxide synthase, inducibleImmunometabolism Pathway (Bacterial Activation)
smpdb.ca/view/SMP0125484DiseaseThe NF-kB protein then goes to nucleus and activates expression of nitric oxide synthase (iNOS) which generates nitric oxide (NO). … Higher nitric oxide (NO) levels lead to blood vessel dilation and reduced blood pressure, which in its most extreme form, can be a major problem in sepsis.
Enzymes: Nitric oxide synthase, inducibleBacterial Sepsis
smpdb.ca/view/SMP0125493DiseaseThe NF-kB protein then goes to nucleus and activates expression of nitric oxide synthase (iNOS) which generates nitric oxide (NO). … Higher nitric oxide (NO) levels lead to blood vessel dilation and reduced blood pressure, which in its most extreme form, can be a major problem in sepsis.
Enzymes: Nitric oxide synthase, inducibleViral Sepsis
smpdb.ca/view/SMP0125490DiseaseThe NF-kB protein then goes to nucleus and activates expression of nitric oxide synthase (iNOS) which generates nitric oxide (NO). … Higher nitric oxide (NO) levels lead to blood vessel dilation and reduced blood pressure, which in its most extreme form, can be a major problem in sepsis.
Enzymes: Nitric oxide synthase, inducibleHIF-1 (Hypoxia) Signaling
smpdb.ca/view/SMP0546631SignalingHypoxia triggers stabilization of hypoxia‑inducible factors (HIFs), oxygen‑sensitive transcription factors that orchestrate adaptive responses by inducing genes involved in angiogenesis, erythropoiesis, metabolism, and survival. Under no...
Enzymes: Nitric oxide synthase, inducible, Nitric oxide synthase, endothelialNicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...
Enzymes: Dimethylaniline monooxygenase [N-oxide-forming] 3