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Displaying results 161 - 170 of 138750 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … Higher circulating levels of five of these N-acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-methylhistidine, N-acetylhistidine, and N2,N5-diacetylornithine,

    Drugs: Histidine · Ademetionine
  2. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … Glutamic acid is carboxylated into 1-Pyrroline-5-carboxylic acid by the enzyme Delta-1-pyrroline-5-carboxylate synthase. 1-Pyrroline-5-carboxylic acid with glutaric acid synthesize Oxoglutaric acid and

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
    Enzymes: Neutral amino acid transporter A, Low affinity cationic amino acid transporter 2
  3. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    Therefore substance P, CGRP, and glutamate are not released into the synapse and cannot activate the substance P receptors, CGRP receptors, or the N-Methyl-D-aspartic acid receptors on the post-synaptic … such as intrathecal morphine and systemic analgesics.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  4. Pathway

    Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (Fatty Acid Elongation in Mitochondria)

    smpdb.ca/view/SMP0125748
    Disease

    Long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, which is also known LCHADD, is a rare inherited inborn error of metabolism (IEM) of long-chain fatty acid metabolism. … HADHA catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids.

    Drugs: NADH · Palmitic Acid
  5. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    Icosapent is an important polyunsaturated fatty acid (eicosapentaenoic acid (EPA)). It is mostly found in fish oils. … This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2).

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    Fish oil is made of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). … These are responsible for the conversion of arachidonic acid (an omega-6 fatty acid) into prostaglandins and thromboxanes, which are important mediators of inflammation and pain.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  7. Pathway

    Valproate bismuth Drug Metabolism

    smpdb.ca/view/SMP0130553
    Metabolic

    Valproate bismuth passes through the liver and is then excreted from the body mainly through the kidney. … Valproate bismuth is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Valproate bismuth
  8. Pathway

    Bismuth subgallate Drug Metabolism

    smpdb.ca/view/SMP0130924
    Metabolic

    Bismuth subgallate passes through the liver and is then excreted from the body mainly through the kidney. … Bismuth subgallate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Bismuth subgallate
  9. Pathway

    Bismuth subcitrate potassium Drug Metabolism

    smpdb.ca/view/SMP0130585
    Metabolic

    Bismuth subcitrate potassium passes through the liver and is then excreted from the body mainly through the kidney. … Bismuth subcitrate potassium is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Bismuth subcitrate potassium
  10. Pathway

    Oxidation of Branched-Chain Fatty Acids

    smpdb.ca/view/SMP0000030
    Metabolic

    Now moving to the mitochondria, there are four reactions that occur, and are repeated for each molecule of the fatty acid. … Unfortunately, traditional fatty acid oxidation does not work for branched-chain fatty acids, or fatty acids that do not have an even number of carbons, like the fatty acid phytanic acid, found in animal

    Drugs: Ascorbic acid · Succinic acid · ATP · Levocarnitine · Magnesium cation · Iron +2 more
    Enzymes: Long-chain-fatty-acid--CoA ligase 1