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Olanzapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126805Drug actionlanzapine is an atypical (second-generation) antipsychotic that exerts its action primarily on dopamine and serotonin receptors. It works on dopamine D2 receptors in the mesolimbic pathway as an antagonist, blocking dopamine from potenti...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Mirtazapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126817Drug actionThe mechanism of action of mirtazapine, atypical antidepressant is not fully understood, but may be explained by its effects on central adrenergic and serotonergic activity. This drug exhibits a fast onset of action, a high level of resp...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Minaprine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126818Drug actionMinaprine binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Cyproheptadine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126842Drug actionCyproheptadine appears to exert its antihistamine and antiserotonin effects by competing with free histamine and serotonin for binding at their respective receptors. Antagonism of serotonin on the appetite center of the hypothalamus may ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Clozapine Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126963Drug actionClozapine is an antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Clozapine is available as oral tablets. Clozapine is part of a group of drugs known as second-generation...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent L-type calcium channel subunit beta-1Ascorbic acid
go.drugbank.com/drugs/DB00126ApprovedInvestigationalNutraceuticalA six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active fo...
Mixtures: Calcium PNV, Calcium PlusCategories: ascorbic acid (vit C) and calciumTrimebutine M3 Receptor Intestine Relaxation Action Pathway
smpdb.ca/view/SMP0126338Drug actionTrimebutine is suggested to bind to the inactivated state of the calcium channel with high affinity. Reduced calcium influx attenuates membrane depolarization and decrease colon peristalsis.
Drugs: ATP · Nitric Oxide · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate +3 moreEnzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent P/Q-type calcium channel subunit alpha-1APhenytoin Action Pathway (New)
smpdb.ca/view/SMP0126264Drug actionPhenytoin is an anticonvulsant drug used in the prophylaxis and control of various types of seizures. It can be found under the brand names Dilantin and Phenytek. Although phenytoin first appeared in the literature in 1946, it has taken ...
Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1GFenethazine H1-Antihistamine Action
smpdb.ca/view/SMP0059707Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: CalciumTemelastine H1-Antihistamine Action
smpdb.ca/view/SMP0062880Drug actionFurthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release.
Drugs: Calcium