Search
Levomilnacipran SNRI - Norepinephrine reuptake Inhibition Action Pathway
smpdb.ca/view/SMP0126430Drug actionLevomilnacipran (the more active 1S, 2R - enantiomer of milnacipran) is a serotonin and norepinephrine reuptake inhibitor (SNRI). It is used in the management of major depressive disorder, generalized anxiety disorder, chronic musculoske...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Sodium-dependent noradrenaline transporterRemoxipride Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126480Drug actionRemoxipride is an atypical antipsychotic dopamine D2 antagonist. Chronic use upregulates the expression of D2 receptors, while downregulating the expression of D1 and D5 receptors in the prefrontal cortex. This activity may be related to...
Enzymes: Sodium-dependent dopamine transporterMesoridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126524Drug actionMesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer and a first generation typical antipsychotic. Based upon animal studies, mesoridazine, as with other phenothiazines, acts indirectly on reti...
Enzymes: Sodium-dependent serotonin transporterThioridazine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126560Drug actionThioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal...
Enzymes: Sodium-dependent serotonin transporterBromopride Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126582Drug actionBromopride is a substituted benzamide. Bromopride in indicated in the treatment of nausea and vomiting, including PONV (post-operative nausea and vomiting), gastroesophageal reflux disease (GERD/GORD), as well as endoscopy preparation an...
Enzymes: Sodium-dependent dopamine transporterPaliperidone Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126592Drug actionPaliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabo...
Enzymes: Sodium-dependent dopamine transporterDosulepin Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126779Drug actionDosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of ...
Enzymes: Sodium-dependent serotonin transporterGranisetron Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126787Drug actionGranisetron is a selective inhibitor of type 3 serotonergic (5-HT3) receptors. Granisetron has little or no affinity for other serotonin receptors, including 5-HT 1 , 5-HT 1A , 5-HT 1B/C , or 5-HT 2 ; for alpha 1 -, alpha 2 -, or beta-ad...
Enzymes: Sodium-dependent serotonin transporterQuetiapine Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126799Drug actionQuetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may ...
Enzymes: Sodium-dependent serotonin transporterLorpiprazole Serotonin antagonist Action Pathway
smpdb.ca/view/SMP0126822Drug actionLorpiprazole is a serotonin antagonist and reuptake inhibitor thus, its activity is performed by antagonizing the 5-HT2A and the 5-HT2C serotoninergic receptors as well as the alpha1 and alpha2 adrenergic receptors, H1 histaminergic rece...
Enzymes: Sodium-dependent serotonin transporter