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Displaying results 171 - 180 of 296 in total
  1. Target

    Cell growth-regulating nucleolar protein

    go.drugbank.com/bio_entities/BE0008958
    TargetMouse

    Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).

    Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264
  2. Target

    Zinc transporter ZIP5

    go.drugbank.com/bio_entities/BE0009888
    TransporterHumans

    Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine … The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509).

    Synonyms: Zrt- and Irt-like protein 5
  3. Target

    Geranyltranstransferase (Farnesyldiphosphate synthase)

    go.drugbank.com/bio_entities/BE0004143
    TargetShigella flexneri

    Synonyms: Geranyltranstransferase,Farnesyl diphosphate synthase,geranyltranstransferase,Geranylgeranyl pyrophosphate synthase,heptaprenyl diphosphate synthase component II,Polyprenyl synthetase
  4. Target

    ADP-ribose pyrophosphatase

    go.drugbank.com/bio_entities/BE0002544
    TargetThermus thermophilus

    Polypeptides: ADP-ribose pyrophosphatase
  5. Target

    Inosine triphosphate pyrophosphatase

    go.drugbank.com/bio_entities/BE0004443
    TargetEnzymeHumans

    Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine … Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions

    Polypeptides: Inosine triphosphate pyrophosphataseSynonyms: Non-canonical purine NTP pyrophosphatase, Non-standard purine NTP pyrophosphatase
  6. Target

    Stabilin-2

    go.drugbank.com/bio_entities/BE0004948
    TargetHumans

    Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS

    Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
  7. Target

    Solute carrier organic anion transporter family member 1B1

    go.drugbank.com/bio_entities/BE0001004
    TransporterTargetCarrierHumans

    , and estrone 3-sulfate), as well as eicosanoids (prostaglandin E2, thromboxane B2, leukotriene C4, and leukotriene E4), and thyroid hormones (T4/L-thyroxine, and T3/3,3',5'-triiodo-L-thyronine) (PubMed … Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540).

    Synonyms: Sodium-independent organic anion-transporting polypeptide 2
  8. Target

    Prolyl 3-hydroxylase 1

    go.drugbank.com/bio_entities/BE0002202
    TargetEnzymeHumans

    Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen

    Synonyms: Leucine- and proline-enriched proteoglycan 1
  9. Target

    Zinc transporter ZIP11

    go.drugbank.com/bio_entities/BE0009906
    TransporterHumans

    Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechan...

    Synonyms: Zrt- and Irt-like protein 11
  10. Target

    Protein phosphatase 1 regulatory subunit 15A

    go.drugbank.com/bio_entities/BE0011888
    TargetHumans

    Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053).

    Synonyms: Growth arrest and DNA damage-inducible protein GADD34