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Displaying results 1841 - 1850 of 10000 in total
  1. Drug

    Methylphenidate

    go.drugbank.com/drugs/DB00422
    ApprovedInvestigational

    In contrast, low doses are found to selectively activate NE and DA neurotransmission within the prefrontal cortex which is an area of the brain thought to play a prominent role in ADHD pathophysiology, … [A177550] Clinical findings have shown that children with ADHD have an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/or the D2 receptor gene that may be at least

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 3-RingSynonyms: methyl α-phenyl-α-(2-piperidyl)acetate, methyl α-phenyl-α-2-piperidinylacetate
  2. Target

    Leucine carboxyl methyltransferase 1

    go.drugbank.com/bio_entities/BE0000450
    TargetHumans

    Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues

    Synonyms: Protein-leucine O-methyltransferaseFunction: protein C-terminal carboxyl O-methyltransferase activity
  3. Drug

    CP-12

    go.drugbank.com/drugs/DB18169
    Investigational

    Synonyms: CYCLIZED P12 (PEPTIDE BOND BETWEEN THE CARBOXY AND AMINO-TERMINAL ENDS OF THE LINEAR PEPTIDE PSHISKYILRWRPK), PROLYL-L-SERYL-L-HISTIDYL-L-ISOLEUCYL-L-SERYL-L-LYSYL-L-TYROSYL-L-ISOLEUCYL-L-LEUCYL- L-ARGINYL-L-TRYPTOPHANYL-L-ARGINYL-L-PROLYL-L-LYSYL), CYCLO (1-14)
  4. Drug

    Threonine

    go.drugbank.com/drugs/DB00156
    ApprovedInvestigationalNutraceutical

    An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.

    Synonyms: L-2-Amino-3-hydroxybutyric acid, L-α-amino-β-hydroxybutyric acidMixtures: Aminosyn II in Dextrose, Aminosyn II in Dextrose
  5. Indication

    Osteoarthritis of the Knee

    go.drugbank.com/conditions/DBCOND0032623
    Drugs: Diacerein · Diclofenac · Dimethyl sulfone · Duloxetine · Glucosamine
    Synonyms: O/A, Osteoarthritis in the Knee
  6. Drug

    Tryptophan

    go.drugbank.com/drugs/DB00150
    ApprovedInvestigationalNutraceuticalWithdrawn

    An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. … It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit inefficiently, in mammals.

    Synonyms: L-β-3-indolylalanine, (2S)-2-amino-3-(1H-indol-3-yl)propanoic acidMixtures: Aminosyn II in Dextrose, Aminosyn II in Dextrose
  7. Drug

    Sulconazole

    go.drugbank.com/drugs/DB06820
    Approved

    Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes, making it an effective treatment for tinea cruris and tinea corporis … [L44592,L44597] Sulconazole appears to be effective and well-tolerated in the treatment of superficial fungal infections.[A255612]

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 Inhibitors
  8. Drug

    Phenylalanine

    go.drugbank.com/drugs/DB00120
    ApprovedInvestigationalNutraceutical

    Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, [dopamine], [noradrenalin] (norepinephrine), and [thyroxine].

    Synonyms: (S)-2-Amino-3-phenylpropionic acid, 3-phenyl-L-alanineMixtures: Aminosyn II in Dextrose, Aminosyn II in Dextrose
  9. Indication

    Alimentary Obesity

    go.drugbank.com/conditions/DBCOND0061821
    Drugs: Diethylpropion · Phendimetrazine
    Synonyms: Alteration in nutrition: more than body requirements (finding)
  10. Indication

    Fetal Status, Nonreassuring

    go.drugbank.com/conditions/DBCOND0155307
    Drugs: Ritodrine
    Synonyms: (Fetal distress) or (meconium in liquor)