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Formoterol Action Pathway
smpdb.ca/view/SMP0126086Drug actionFormoterol is a long acting beta-2 adrenergic receptor agonist that is used as a bronchodilator and to manage asthma and COPD. It can be used as well for prophylaxis against exercise induced bronchospasm. This drug is inhaled and can be ...
Drugs: ATP · Formoterol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126043Drug actionRitodrine is a adrenergic beta agonist used for the treatment and prophylaxis of premature labour. Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adren...
Drugs: ATP · Ritodrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphateEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12Zolmitriptan Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126995Drug actionZolmitriptan, like other triptans, is a serotonin (5-hydroxytryptamine; 5-HT) receptor agonist, with enhanced specificity for the 5-HT1B and 5-HT1D receptor subtypes. It is through the downstream effects of 5-HT1B/1D activation that trip...
Drugs: ATP · Zolmitriptan · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acidEnzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Dipivefrin A2-Adrenergic Vasocontriction Action Pathway
smpdb.ca/view/SMP0126098Drug actionDipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Methylhistidine Metabolism
smpdb.ca/view/SMP0000715MetabolicIt is also formed from the methylation of L-histidine, which takes the methyl group from S-adenosylmethionine and forms S-adenosylhomocysteine as a byproduct.
Mercaptopurine Action Pathway
smpdb.ca/view/SMP0000428Drug actionMercaptopurine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis ...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +26 moreEnzymes: Thiopurine S-methyltransferaseAzathioprine Action Pathway
smpdb.ca/view/SMP0000427Drug actionAzathioprine is a purine antimetabolite prodrug that exerts cytotoxic effects via three mechanisms: via incorporation of thiodeoxyguanosine triphosphate into DNA and thioguanosine triphosphate into RNA, inhibition of de novo synthesis of...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreEnzymes: Thiopurine S-methyltransferase1-Methylhistidine Metabolism
smpdb.ca/view/SMP0124716MetabolicIt is also formed from the methylation of L-histidine, which takes the methyl group from S-adenosylmethionine and forms S-adenosylhomocysteine as a byproduct.
Thioguanine Action Pathway (old)
smpdb.ca/view/SMP0000430Drug actionThioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreEnzymes: Thiopurine S-methyltransferaseCitalopram Mechanism of Action Action Pathway New
smpdb.ca/view/SMP0126506Drug actionCitalopram is produced as a racemate - a mixture of two stereoisomers: R-citalopram and S-citalopram (escitalopram is the therapeutic active S- enantiomer of citalopram).