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Sodium/potassium-transporting ATPase subunit beta-3
go.drugbank.com/bio_entities/BE0005026TransporterTargetHumansThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-3Synonyms: Sodium/potassium-dependent ATPase subunit beta-3Sodium/potassium-transporting ATPase subunit alpha-2
go.drugbank.com/bio_entities/BE0005034TargetTransporterHumansThis process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529) … It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-2Synonyms: Sodium pump subunit alpha-2Sodium/potassium-transporting ATPase subunit alpha-3
go.drugbank.com/bio_entities/BE0005047TargetTransporterHumansIn the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933 … Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-3Synonyms: Sodium pump subunit alpha-3Sodium-coupled neutral amino acid symporter 1
go.drugbank.com/bio_entities/BE0009870TransporterHumansSymporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). … The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391).
Polypeptides: Sodium-coupled neutral amino acid symporter 1Sodium-coupled neutral amino acid symporter 2
go.drugbank.com/bio_entities/BE0009871TransporterHumansThe transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. … Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10930503, PubMed:15774260, PubMed:15922329, PubMed:16621798
Polypeptides: Sodium-coupled neutral amino acid symporter 2Intermediate conductance calcium-activated potassium channel protein 4
go.drugbank.com/bio_entities/BE0000415TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 25 picosiemens (PubMed:9326665 … Following calcium influx, the consecutive activation of KCNN4 channel leads to a hyperpolarization of the cell membrane potential and hence an increase of the electrical driving force for further calcium
Polypeptides: Intermediate conductance calcium-activated potassium channel protein 4Function: calcium-activated potassium channel activityDual specificity mitogen-activated protein kinase kinase 1
go.drugbank.com/bio_entities/BE0000870TargetHumansBinding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. … RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2.
Polypeptides: Dual specificity mitogen-activated protein kinase kinase 1Synonyms: ERK activator kinase 1Small conductance calcium-activated potassium channel protein 3
go.drugbank.com/bio_entities/BE0004427TargetHumansThe current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:12808432 … Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values,
Polypeptides: Small conductance calcium-activated potassium channel protein 3Mitogen-activated protein kinase kinase kinase kinase 1
go.drugbank.com/bio_entities/BE0009470TargetHumansActivator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. … MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase kinase 2
go.drugbank.com/bio_entities/BE0009471TargetHumansActs as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs … Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 2