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Displaying results 181 - 190 of 160885 in total
  1. Pathway

    Naloxone Action Pathway

    smpdb.ca/view/SMP0000688
    Drug action

    In recent study, naloxone shows that it can also bind to kappa and gamma-opioid receptors.

    Drugs: ATP · Norepinephrine · Dopamine · Naloxone · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  2. Pathway

    Cocaine Action Pathway

    smpdb.ca/view/SMP0000395
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Cocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  3. Pathway

    Dibucaine Action Pathway

    smpdb.ca/view/SMP0000396
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cinchocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  4. Pathway

    Levobupivacaine Action Pathway

    smpdb.ca/view/SMP0000397
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Levobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Dopamine · Levobupivacaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  5. Pathway

    Lidocaine (Local Anaesthetic) Action Pathway

    smpdb.ca/view/SMP0000398
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: NADH · ATP · Lidocaine · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  6. Pathway

    Oxybuprocaine Action Pathway

    smpdb.ca/view/SMP0000400
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Oxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons.

    Drugs: ATP · Norepinephrine · Oxybuprocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  7. Pathway

    Procaine Action Pathway

    smpdb.ca/view/SMP0000402
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Procaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Procaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  8. Pathway

    Hydromorphone Action Pathway

    smpdb.ca/view/SMP0000410
    Drug action

    The binding of hydromorphone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Hydromorphone · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  9. Pathway

    Hydrocodone Action Pathway

    smpdb.ca/view/SMP0000411
    Drug action

    The binding of hydrocodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Hydrocodone · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha
  10. Pathway

    Alfentanil Action Pathway

    smpdb.ca/view/SMP0000413
    Drug action

    The binding of alfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. … Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein.

    Drugs: ATP · Norepinephrine · Alfentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium channel protein type 10 subunit alpha