Search

Displaying results 181 - 190 of 2123 in total
  1. Pathway

    Dopamine Action Pathway

    smpdb.ca/view/SMP0127069
    Physiological

    Protein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell. … Dopamine is a neurotransmitter that can be taken as a tablet for hemodynamic imbalances caused by many heart problems and diseases.

    Drugs: Ascorbic acid · ATP · Norepinephrine · Dopamine · Calcium · Pyrroloquinoline Quinone
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  2. Pathway

    Hypophosphatasia

    smpdb.ca/view/SMP0125622
    Disease

    Infantile hypophosphatasia, also called I-HPP, is a severe, rare and fatal metabolic bone disease and an inborn error of metabolism. … Early symptoms of the disorder include poor feeding, irritability, hypotonia (state of low muscle tone), failure to thrive and seizures..

    Drugs: Pyridoxal phosphate · Pyridoxal · Pyridoxine · Magnesium cation · Zinc · Pyridoxamine-5'-Phosphate +3 more
  3. Pathway

    Gamma-Aminobutyric Acid Biosynthesis

    smpdb.ca/view/SMP0125090
    Metabolic

    Glutamate is catalyzed in the neuron with the enzyme Glutamate decarboxylase-1 to synthesize GABA and a byproduct of carbon dioxide. … The vesicle is activated by calcium entering the presynapse as well as cAMP.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  4. Pathway

    GABA

    smpdb.ca/view/SMP0127038
    Physiological

    When an action potential reaches the presynaptic cell, voltage-gated calcium channels open and calcium binds to synaptobrevin, which results in the fusion of the vesicle with the plasma membrane and releases … The GABA-B receptor functions via a metabotropic G-protein coupled receptor which increases postsynaptic potassium conductance and decreases presynaptic calcium conductance, which consequently hyperpolarizes

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  5. Pathway

    Butalbital Action Pathway

    smpdb.ca/view/SMP0126149
    Drug action

    Barbiturates potentiate GABA-induced increases in chloride conductance and depress voltage-activated calcium currents while prolonging the duration of GABA-induced chloride channel opening. … , and ethanol.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Butalbital · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  6. Pathway

    Halothane GABA(A) Anesthetic Action Pathway

    smpdb.ca/view/SMP0126161
    Drug action

    Halothane's effect are also likely due to binding to NMDA and calcium channels, causing hyperpolarization. … It also acts as an NMDA receptor antagonist, inhibits nACh and voltage-gated sodium channels, and activates 5-HT3 and twin-pore K+ channels.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Halothane · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  7. Pathway

    Sevoflurane GABA(A) Anesthetic Action Pathway

    smpdb.ca/view/SMP0126170
    Drug action

    Sevoflurane is expected to exert its action via a majority of mechanisms, including GABA(A) agonism, glycine agonism, glutamate antagonism, inhibiting calcium transporting ATPases, and activating potassium … It can be found under the brand names Sevorane, Sojourn, and Ultane. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Sevoflurane · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  8. Pathway

    Ethosuximide Action Pathway

    smpdb.ca/view/SMP0126318
    Drug action

    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone … T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Ethosuximide · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  9. Pathway

    Trimethadione Action Pathway

    smpdb.ca/view/SMP0126340
    Drug action

    This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. … Possible side effects of using trimethadione may include tiredness, changes in weight, hiccups, and headache.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Trimethadione · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  10. Pathway

    Desflurane GABA(A) Anesthetic Action Pathway

    smpdb.ca/view/SMP0126151
    Drug action

    Desflurane is also an agonist of glycine receptors, antagonist of glutamate receptors, inducer of potassium voltage gated channels, and inhibits both NADH-ubiquinone oxioreductase chain and calcium transporting … Some side effects of using desflurane may include bluish lips and/or skin, body aches, and congestion.

    Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Desflurane · Calcium · Magnesium cation +3 more
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A