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Displaying results 181 - 190 of 818 in total
  1. Pathway

    Prilocaine Action Pathway

    smpdb.ca/view/SMP0000401
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Prilocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Prilocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Prilocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Ropivacaine Action Pathway

    smpdb.ca/view/SMP0000404
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Ropivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Ropivacaine · Norepinephrine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Oxycodone Action Pathway

    smpdb.ca/view/SMP0000409
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of oxycodone will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Oxycodone · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Fentanyl Action Pathway

    smpdb.ca/view/SMP0000415
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of carfentanil will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Fentanyl · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Dezocine Action Pathway

    smpdb.ca/view/SMP0000676
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of dezocine will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Dopamine · Dezocine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Dihydromorphine Action Pathway

    smpdb.ca/view/SMP0000689
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of dihydromorphine acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Dihydromorphine
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Ketobemidone Action Pathway

    smpdb.ca/view/SMP0000690
    Drug action

    Hyperpolarization of neuron is caused by inactivation of calcium channels and activation of potassium channels via facilitated by G-protein. … The binding of ketobemidone acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter.

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Ketobemidone
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Indication

    Dry Mouth

    go.drugbank.com/conditions/DBCOND0038951
    Drugs: Amifostine · Calcium chloride · Cevimeline · Glycerin · Pilocarpine · Potassium chloride
  9. Pathway

    Cocaine Action Pathway

    smpdb.ca/view/SMP0000395
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Cocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Cocaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Dibucaine Action Pathway

    smpdb.ca/view/SMP0000396
    Drug action

    Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. … Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form.

    Drugs: ATP · Norepinephrine · Cinchocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1