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Electroneutral sodium bicarbonate exchanger 1
go.drugbank.com/bio_entities/BE0004680TransporterTargetHumansMediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). … Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)
Polypeptides: Electroneutral sodium bicarbonate exchanger 1Function: bicarbonate transmembrane transporter activitySodium Depletion
go.drugbank.com/conditions/DBCOND0093130Drugs: Sodium chlorideSynonyms: Hypo-osmolality and hyponatremia, Sodium DepletionBisacodyl
go.drugbank.com/drugs/DB09020ApprovedInvestigational[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).
Mixtures: HalfLytely and Bisacodyl, HalfLytely and BisacodylCategories: Alimentary Tract and MetabolismPolyethylene glycol
go.drugbank.com/drugs/DB09287ApprovedInvestigationalVet approvedPEGs differ in their physical and chemical properties depending on their molecular weight: PEGs are liquids when molecular weights are <1000 and the molecule turns to waxy solids with increasing molecular … [A190975] Molecular weights of PEGs vary by time of the polymerization process and the molecular weight represents the weighted average of the individual PEG molecules.
Mixtures: Polyethylene Glycol-3350, Sodium Chloride, Potassium Chloride and Sodium Bicarbonate, PEG-3350, sodium chloride, sodium bicarbonate and potassium chlorideCategories: Alimentary Tract and MetabolismCalcium carbonate
go.drugbank.com/drugs/DB06724ApprovedInvestigationalAn increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. Calcium carbonate may also be used as a nutritional supplement or to treat hypocalcemia. … Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions.
Mixtures: GASCID Suspension (Sodium Alginate + Sodium Bicarbonate + Calcium Carbonate), Up and Up Dual Action Acid Reducer and AntacidCategories: Antacids and Adsorbents, Alimentary Tract and MetabolismHypovolaemia
go.drugbank.com/conditions/DBCOND0015822Drugs: Albumin human · Calcium chloride · Gelatin · Hydroxyethyl Starch · Potassium chloride · Sodium acetate +1 moreSynonyms: Sodium and water depletion, Depletion of volume of plasma AND/OR extracellular fluidPendrin
go.drugbank.com/bio_entities/BE0009874TransporterHumansSodium-independent transporter of chloride and iodide (PubMed:10192399, PubMed:11932316, PubMed:12107249, PubMed:16684826, PubMed:24051746). … Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry (PubMed:10644529, PubMed:15155570, PubMed:24051746, PubMed:35601831).
Synonyms: Sodium-independent chloride/iodide transporterFunction: chloride transmembrane transporter activityCyclothiazide
go.drugbank.com/drugs/DB00606ApprovedAs a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. … Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter.
Categories: cyclothiazide and potassium, Genito Urinary System and Sex HormonesElectrolyte imbalance
go.drugbank.com/conditions/DBCOND0015850Synonyms: Fluid/electrolyte/acid-base or electrolyte disorders (& [potassium] or [sodium]), Disorder of fluid AND/OR electrolyte (disorder)