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Galactosemia II (GALK)
smpdb.ca/view/SMP0000495DiseaseGalactokinase uses 1 ATP to catalyse the phosphorylation of α-D-galactose to galactose 1-phosphate and catalyses β-D-galactose to glucose 1-phosphate. … Treatment includes immediately removing lactose from patient’s diet, however symptoms such as delayed speech, cognitive learning and motor skills can still be present.
Enzymes: UDP-glucuronic acid decarboxylase 1Galactosemia II (GALK)
smpdb.ca/view/SMP0125606DiseaseGalactokinase uses 1 ATP to catalyse the phosphorylation of α-D-galactose to galactose 1-phosphate and catalyses β-D-galactose to glucose 1-phosphate. … Treatment includes immediately removing lactose from patient’s diet, however symptoms such as delayed speech, cognitive learning and motor skills can still be present.
Enzymes: UDP-glucuronic acid decarboxylase 1Transaldolase Deficiency
smpdb.ca/view/SMP0125655DiseaseTransaldolase is an enzyme that reversibly converts D-erythrose 4-phosphate and fructose 6-phosphate to D-sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate, as a part of the pentose phosphate … Other signs include abnormal concentrations of polyols in urine and plasma, as well as ribose-, xylulose-, and ribulose-5-phosphate being elevated in urine.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreRibose-5-phosphate Isomerase Deficiency
smpdb.ca/view/SMP0125654DiseaseThere are other symptoms, including leukoencephalopathy and neuropathy, which may be caused by a toxic accumulation of ribitol and arabitol, or a potential lack of ribose-5-phosphate in RNA synthesis. … This combination meant that activity of RPI was found to vary across tissues and cell types.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreGLUT-1 Deficiency Syndrome
smpdb.ca/view/SMP0000580DiseaseThis disorder is characterized by dissipation of D-glucose in both Golgi apparatus and cell cytoplasm. Symptoms of the disorder include developmental delays of mental and motor. … GLUT1 deficiency syndrome, also called GLUT1-DS or De Vivo disease, is an autosomal dominant disorder and caused by a defective solute carrier family 2, facilitated glucose transporter member 1.
Ribose-5-phosphate Isomerase Deficiency
smpdb.ca/view/SMP0000519DiseaseThere are other symptoms, including leukoencephalopathy and neuropathy, which may be caused by a toxic accumulation of ribitol and arabitol, or a potential lack of ribose-5-phosphate in RNA synthesis. … This combination meant that activity of RPI was found to vary across tissues and cell types.
Drugs: Adenosine phosphate · ATP · Magnesium cation · Iron · 5-O-phosphono-alpha-D-ribofuranosyl diphosphate · D-glyceraldehyde 3-phosphate +4 moreAripiprazole Dopamine agonist Action Pathway
smpdb.ca/view/SMP0126454Drug actionAripiprazole may be administered with or without food and is available in oral tablets, disintegrating tablets (10 mg and 15 mg), oral solution, and intramuscular (IM) injections for acute symptoms and … It has a high affinity for D2, D3, 5HT-1a, and 5HT2a receptors and moderate affinity for D4, 5HT-2c, 5-HT7, alpha-1 adrenergic, and H1 receptors.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorFluphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126501Drug actionFluphenazine blocks postsynaptic dopaminergic D1 and D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways in the brain; depresses the release of hypothalamic and hypophyseal … hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptorFacial rash
go.drugbank.com/conditions/DBCOND0098014Drugs: Zinc oxideSynonyms: Rash and other nonspecific skin eruptionSelegiline Action Pathway
smpdb.ca/view/SMP0126719Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B.
Enzymes: Aromatic-L-amino-acid decarboxylase, D(2) dopamine receptor