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Displaying results 191 - 200 of 1567 in total
  1. Pathway

    Dibucaine Action Pathway

    smpdb.ca/view/SMP0000396
    Drug action

    Dibucaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Dibucaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...

    Drugs: ATP · Norepinephrine · Cinchocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  2. Pathway

    Levobupivacaine Action Pathway

    smpdb.ca/view/SMP0000397
    Drug action

    Levobupivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Levobupivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it i...

    Drugs: ATP · Norepinephrine · Dopamine · Levobupivacaine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  3. Pathway

    Lidocaine (Local Anaesthetic) Action Pathway

    smpdb.ca/view/SMP0000398
    Drug action

    Lidocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Lidocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated...

    Drugs: NADH · ATP · Lidocaine · Norepinephrine · Dopamine · Potassium cation +3 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  4. Pathway

    Oxybuprocaine Action Pathway

    smpdb.ca/view/SMP0000400
    Drug action

    Oxybuprocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Oxybuprocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is pr...

    Drugs: ATP · Norepinephrine · Oxybuprocaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  5. Pathway

    Procaine Action Pathway

    smpdb.ca/view/SMP0000402
    Drug action

    Procaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Procaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated a...

    Drugs: ATP · Norepinephrine · Procaine · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  6. Pathway

    Sufentanil Action Pathway

    smpdb.ca/view/SMP0000417
    Drug action

    Sufentanil is a pharmacologically-active synthetic small molecule derived from fentanyl and belongs to a class of drugs called opioids. Opioids are therapeutically employed to achieve analgesia. Sufentanil’s rapid mechanism of action pri...

    Drugs: ATP · Norepinephrine · Sufentanil · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  7. Pathway

    Desipramine Action Pathway

    smpdb.ca/view/SMP0000423
    Drug action

    Desipramine is a tricyclic antidepressant that exerts its therapeutic effects by inhibiting norepinephrine and serotonin reuptake in the brain. It does so by competing for the same binding site as norepinephrine on the sodium-dependent n...

    Drugs: ATP · Norepinephrine · Dopamine · Desipramine · Potassium cation · Calcium +1 more
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  8. Pathway

    Escitalopram Action Pathway

    smpdb.ca/view/SMP0000425
    Drug action

    Escitalopram is a selective serotonin reuptake inhibitor that exerts antidepressive effects by selectively inhibiting serotonin reuptake in the brain. It does so by competing for the same binding site as serotonin on the the sodium-depen...

    Drugs: ATP · Norepinephrine · Dopamine · Escitalopram · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  9. Pathway

    Levorphanol Action Pathway

    smpdb.ca/view/SMP0000673
    Drug action

    Levorphanol (also known as Levo-Dromoran) is an opioid medication that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellu...

    Drugs: ATP · Norepinephrine · Levorphanol · Dopamine · Potassium cation · Calcium
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1
  10. Pathway

    Methadyl Acetate Action Pathway

    smpdb.ca/view/SMP0000678
    Drug action

    Methadyl Acetate (also known as Acetylmethadol) is a synthetic opioid analgesic that can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level...

    Drugs: ATP · Norepinephrine · Dopamine · Potassium cation · Calcium · Methadyl acetate
    Enzymes: Sodium/potassium-transporting ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit beta-1