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Metoclopramide - Dopamine Antagonist Action Pathway
smpdb.ca/view/SMP0126993Drug actionMetoclopramide is a dopamine receptor antagonist and has been approved by the FDA to treat nausea and vomiting in patients with gastroesophageal reflux disease or diabetic gastroparesis by increasing gastric motility.. Metoclopramide wor...
Enzymes: Sodium-dependent dopamine transporterThroat irritation
go.drugbank.com/conditions/DBCOND0010471Drugs: Benzydamine · Cetylpyridinium · Pentoxyverine · Phenol · Pholcodine · Pseudoephedrine +1 moreLurasidone Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126527Drug actionLurasidone is is a benzothiazol derivative and an atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Lurasidone is an atypical antipsychotic that is a D2 and 5-HT2A (mixed serot...
Enzymes: Sodium-dependent serotonin transporterPerphenazine Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126530Drug actionPerphenazine is a piperazinyl phenothiazine first generation antipsychotic that acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine m...
Enzymes: Sodium-dependent dopamine transporterAmisulpride Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126531Drug actionAmisulpride, a substituted benzamide derivative, is a second-generation (atypical) antipsychotic. Amisulpride is a selective dopamine D2 and D3 receptor antagonist with no affinity towards other dopamine receptor subtypes. At low doses, ...
Enzymes: Sodium-dependent serotonin transporterAcepromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126586Drug actionAcepromazine is a phenothiazine tranquilizer that blocks dopamine receptors in the CNS and depresses the reticular-activating system, resulting in sedation. Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It...
Enzymes: Sodium-dependent serotonin transporterRotigotine Dopamine Agonist Action Pathway
smpdb.ca/view/SMP0126641Drug actionRotigotine is an agonist at all 5 dopamine receptor subtypes (D1-D5) but binds to the D3 receptor with the highest affinity. It is delivered continuously through the skin (transdermal) using a silicone-based patch that is replaced every ...
Enzymes: Sodium-dependent dopamine transporterBrexpiprazole Serotonin Action Action Pathway
smpdb.ca/view/SMP0126699Drug actionAlthough the exact mechanism of action of brexpiprazole in psychiatric disorders has not been fully elucidated, the efficacy of brexpiprazole may be attributed to combined partial agonist activity at 5-HT1A and dopamine D2 receptors, and...
Enzymes: Sodium-dependent serotonin transporterChlorpromazine - Serotonin Antagonist Action Pathway
smpdb.ca/view/SMP0126487Drug actionProchlorperazine and chlorpromazine are examples of this class of Phenothiazines. Phenothiazines antagonize the D2 receptor, most notably in the area postrema in the brain. IV, PO, and rectal (PR) formulations are available. Side effects...
Enzymes: Sodium-dependent serotonin transporterAmoxapine SSRI Action Pathway
smpdb.ca/view/SMP0126502Drug actionAmoxapine is a second-generation tricyclic dibenzoxazepine antidepressant, chemically distinct from the dibenzodiazepines, dibenzocycloheptenes, and dibenzoxepines. It has a mild sedative component to its action. The mechanism of its cli...
Enzymes: Sodium-dependent serotonin transporter