Search
Bevantolol Beta Blocker Cardiac Action Pathway
smpdb.ca/view/SMP0122915Drug actionBevantolol is a beta blocker and calcium channel blocker. It is an oral drug used for the treatment of angina pectoris and hypertension. … Protein kinase is required to activate calcium channels in the cell membrane, causing them to open and allow Ca2+ to enter the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GArbutamine Action Pathway
smpdb.ca/view/SMP0123258Drug actionProtein kinase activates calcium channels in the membrane, causing them to open and allow Ca2+ to enter the cell. Due to this effect, there is high concentration of Ca2+ in the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GEphedrine B1-Adrenergic Cardiac Muscle Constriction Action Pathway
smpdb.ca/view/SMP0126497Drug actionProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GNorepinephrine Beta-1 Adrenergic Cardiac Action Pathway
smpdb.ca/view/SMP0126438Drug actionThe voltage-gated calcium channels allow calcium to enter the cell. The calcium activates the ryanodine receptor on the sarcoplasmic reticulum in order to release more calcium into the cytosol. … This receptor activates the G-coupled receptor cascase which activates cAMP-dependent protein kinase which activates voltage-gated calcium channels.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GPindolol B1-Adrenergic Cardiac Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126651Drug actionIncreased intracellular calcium increase inotropy in the heart through calcium-induced exchange facilitated by the sarcoplasmic reticulum. … Beta-1 receptors are G-protein-coupled receptors (specifically Gs alpha subunit) whose action is exerted through the cyclic AMP (cAMP) and cAMP-dependent protein kinase action with resultant calcium ion
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1GDopamine Action Pathway
smpdb.ca/view/SMP0125137Drug actionProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1ADopamine Action Pathway
smpdb.ca/view/SMP0127069PhysiologicalProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1ADroxidopa B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0126078Drug actionProtein kinase activates calcium channels in the membrane, causing the channels to open and allow Ca2+ into the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent P/Q-type calcium channel subunit alpha-1ANeostigmine Action Pathway (new)
smpdb.ca/view/SMP0126669Drug actionWhen an action potential arrives at the nerve terminal, voltage-gated calcium channels open leading to an influx of calcium ions into the neuron. … The sodium causes depolarization of the cell, opening voltage-gated calcium channels on the sarcoplasmic reticulum. Calcium enters the cytosol from the sarcoplasmic reticulum and binds to calmodulin.
Enzymes: Voltage-dependent L-type calcium channel subunit beta-4, Voltage-dependent L-type calcium channel subunit alpha-1FIsoprenaline B1-Adrenergic Cardiac Muscle Contraction Action Pathway
smpdb.ca/view/SMP0122740Drug actionProtein kinase activates calcium channels in the membrane, causing them to open and allow Ca2+ to enter the cell. Due to this effect, there is high concentration of Ca2+ in the cell.
Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G