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Displaying results 21 - 30 of 251 in total
  1. Target

    Potassium channel subfamily K member 2

    go.drugbank.com/bio_entities/BE0000210
    TargetHumans

    Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). … In hippocampal astrocytes, the heterodimer of KCNK2/TREK-1 and KCNK1/TWIK-1 allows passive K(+) conductance under basal conditions, but changes ion selectivity and becomes permeable to L-glutamate and

    Polypeptides: Potassium channel subfamily K member 2Synonyms: Two pore potassium channel TPKC1, Two pore domain potassium channel TREK1
  2. Target

    Potassium-transporting ATPase ATP-binding subunit

    go.drugbank.com/bio_entities/BE0003296
    TargetEscherichia coli (strain K12)

    This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm (PubMed:16354672, PubMed:30478378, PubMed:34272288). … Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:23930894,

    Polypeptides: Potassium-transporting ATPase ATP-binding subunitSynonyms: Potassium-binding and translocating subunit B, Potassium-translocating ATPase B chain
  3. Target

    Sodium/potassium-transporting ATPase subunit gamma

    go.drugbank.com/bio_entities/BE0000229
    TargetEnzymeTransporterHumans

    May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase

    Polypeptides: Sodium/potassium-transporting ATPase subunit gamma
  4. Target

    Potassium channel subfamily K member 3

    go.drugbank.com/bio_entities/BE0003582
    TargetHumans

    and adaptive thermogenesis (By similarity) … Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:23169818, PubMed:32499642).

    Polypeptides: Potassium channel subfamily K member 3Synonyms: Two pore potassium channel KT3.1, Acid-sensitive potassium channel protein TASK-1
  5. Target

    Potassium channel subfamily T member 1

    go.drugbank.com/bio_entities/BE0015369
    TargetHumans

    Contributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).

    Polypeptides: Potassium channel subfamily T member 1Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2
  6. Target

    Potassium channel subfamily T member 2

    go.drugbank.com/bio_entities/BE0015626
    TargetHumans

    Sodium-activated and chloride-activated potassium channel (PubMed:14684870, PubMed:16687497, PubMed:25214519, PubMed:27682982, PubMed:29069600, PubMed:29740868).

    Polypeptides: Potassium channel subfamily T member 2Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1, Sequence like an intermediate conductance potassium channel subunit
  7. Target

    Potassium channel subfamily K member 18

    go.drugbank.com/bio_entities/BE0016097
    TargetHumans

    Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. … K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively.

    Polypeptides: Potassium channel subfamily K member 18Synonyms: TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel
  8. Target

    Potassium channel subfamily K member 1

    go.drugbank.com/bio_entities/BE0000154
    TargetHumans

    The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:15820677, PubMed:21653227, PubMed:22431633 … Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677

    Polypeptides: Potassium channel subfamily K member 1Synonyms: Potassium channel K2P1, Potassium channel KCNO1
  9. Target

    Potassium-transporting ATPase alpha chain 1

    go.drugbank.com/bio_entities/BE0000349
    TargetHumans

    Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing … Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell (By similarity).

    Polypeptides: Potassium-transporting ATPase alpha chain 1
  10. Target

    Potassium channel subfamily K member 6

    go.drugbank.com/bio_entities/BE0000680
    TargetHumans

    Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (By similarity) … Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection.

    Polypeptides: Potassium channel subfamily K member 6Synonyms: Inward rectifying potassium channel protein TWIK-2