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Displaying results 21 - 30 of 296 in total
  1. Target

    Sodium-dependent noradrenaline transporter

    go.drugbank.com/bio_entities/BE0000486
    TargetTransporterHumans

    Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921, PubMed:39395208, PubMed:39048818) … Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:2008212, PubMed

    Polypeptides: Sodium-dependent noradrenaline transporter
  2. Target

    Sodium-dependent dopamine transporter

    go.drugbank.com/bio_entities/BE0000647
    TargetTransporterHumans

    Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). … Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:11093780, PubMed:1406597, PubMed:15505207, PubMed:19478460, PubMed:39112701, PubMed:39112703, PubMed:39112705, PubMed

    Polypeptides: Sodium-dependent dopamine transporter
  3. Target

    Sodium-dependent serotonin transporter

    go.drugbank.com/bio_entities/BE0000749
    TargetTransporterHumans

    Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. … Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle.

    Polypeptides: Sodium-dependent serotonin transporter
  4. Target

    Sodium/hydrogen exchanger 1

    go.drugbank.com/bio_entities/BE0000752
    TargetTransporterHumans

    Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism … Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival (PubMed:12947095, PubMed:15096511, PubMed:22020933,

    Polypeptides: Sodium/hydrogen exchanger 1
  5. Target

    Sodium bicarbonate cotransporter 3

    go.drugbank.com/bio_entities/BE0004676
    TransporterHumans

    Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). … Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity

    Polypeptides: Sodium bicarbonate cotransporter 3Synonyms: Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b
  6. Target

    Sodium/nucleoside cotransporter 1

    go.drugbank.com/bio_entities/BE0004705
    TransporterHumans

    Sodium and pyrimidine nucleoside symporter of the plasma membrane that imports uridine, thymidine and cytidine into cells by coupling their transport to the transmembrane sodium electrochemical gradient … Also transports adenosine, an atypical substrate transported with high apparent affinity, but low maximum velocity.

    Polypeptides: Sodium/nucleoside cotransporter 1Synonyms: Sodium-coupled nucleoside transporter 1
  7. Target

    Sodium/glucose cotransporter 2

    go.drugbank.com/bio_entities/BE0004753
    TargetTransporterHumans

    Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Tran...

    Polypeptides: Sodium/glucose cotransporter 2Synonyms: Low affinity sodium-glucose cotransporter
  8. Target

    Sodium/glucose cotransporter 1

    go.drugbank.com/bio_entities/BE0004754
    TransporterTargetHumans

    Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity) (PubMed:8563765 … Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine

    Polypeptides: Sodium/glucose cotransporter 1Synonyms: High affinity sodium-glucose cotransporter
  9. Target

    Sodium/nucleoside cotransporter 2

    go.drugbank.com/bio_entities/BE0004781
    TransporterHumans

    Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). … Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697).

    Polypeptides: Sodium/nucleoside cotransporter 2Synonyms: Sodium-coupled nucleoside transporter 2, Sodium/purine nucleoside co-transporter
  10. Target

    Sodium/hydrogen exchanger 3

    go.drugbank.com/bio_entities/BE0009757
    TargetTransporterHumans

    Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773) … Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity).

    Polypeptides: Sodium/hydrogen exchanger 3