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3-beta-Hydroxysteroid Dehydrogenase Deficiency
smpdb.ca/view/SMP0000718Disease3-beta-hydroxysteroid dehydrogenase (HSD) deficiency is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect in the HSD3B2 gene which encodes for th...
Immunometabolism Pathway (Viral Activation)
smpdb.ca/view/SMP0125488DiseaseThe normal response to a virus infection involves viral coat proteins activating the Toll-like receptors TLR4 and TLR2 on the membranes of macrophages, T-cells and dendritic cells. In addition to this protein activation, the viral DNA (o...
Bacterial Sepsis
smpdb.ca/view/SMP0125493DiseaseBacterial sepsis begins when bacteria activate the Toll-like receptor TLR4 on the membranes of macrophages, T-cells and dendritic cells. TLR4 activates the production of interferon regulatory factor 3 (IRF3), TIR-domain-containing adapte...
Vitamin A Deficiency
smpdb.ca/view/SMP0125788DiseaseVitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two s...
Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
smpdb.ca/view/SMP0125797DiseaseAdrenal hyperplasia type 3, also called Congenital adrenal hyperplasia due to 21-hydroxylase deficiency, is caused by a defect in the CYP21A2 gene which codes for Steroid 21-hydroxylase (21-hydroxylase). Steroid 21-hydroxylase catalyzes ...
3-beta-Hydroxysteroid Dehydrogenase Deficiency
smpdb.ca/view/SMP0125804Disease3-beta-hydroxysteroid dehydrogenase (HSD) deficiency is an extremely rare inborn error of metabolism (IEM) and autosomal recessive disorder of the steroidogenesis pathway. It is caused by an defect in the HSD3B2 gene which encodes for th...
Cortisone Acetate Action Pathway
smpdb.ca/view/SMP0126207Drug actionCortisone acetate is a steroid hormone approved by the FDA since 1950. It is used for the relief of a wide variety of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, an...
Drugs: Glutathione · Hydrocortisone · Dinoprostone · Calcium · Cortisone acetate · Prostaglandin D2 +4 moreHydrocortisone Action Pathway
smpdb.ca/view/SMP0126250Drug actionHydrocortisone, also known as Cortisol, is a glucocorticoid used to treat corticosteroid-responsive dermatoses, endocrine disorders, immune conditions, and allergic disorders. It is naturally secreted by the adrenal cortex. Hydrocortison...
Triamcinolone Action Pathway
smpdb.ca/view/SMP0126251Drug actionTriamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions. As this drug is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) influencing COX-2/prostaglandin G/H...
Clindamycin Action Pathway
smpdb.ca/view/SMP0000249Drug actionClindamycin is a natural antibiotic that produced by Streptomyces lincolnensis, which can be used for treating various bacterial infections by binding and inhibiting 23S portion of 50S subunit of ribosomes. Blocking the portion of riboso...
Drugs: Clindamycin