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Lysophosphatidic Acid LPA1 Signalling
smpdb.ca/view/SMP0063746SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).
Enzymes: Lysophosphatidic acid receptor 1Lysophosphatidic Acid LPA3 Signalling
smpdb.ca/view/SMP0063755SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. … LPC, LPE, LPS) into LPA via autotaxin (ATX/Enpp2) and (2) the conversion of phosphatidic acid (PA) into LPA via phospholipase A1 or A2 (PLA1/PLA2).
Enzymes: Lysophosphatidic acid receptor 3Gamma-Aminobutyric Acid Biosynthesis
smpdb.ca/view/SMP0125090MetabolicGlutamate is catalyzed in the neuron with the enzyme Glutamate decarboxylase-1 to synthesize GABA and a byproduct of carbon dioxide. … GABA is transported into a synaptic vesicle by Vesicular inhibitory amino acid transporter. The vesicle is activated by calcium entering the presynapse as well as cAMP.
Drugs: Pyridoxal phosphate · Glutamic acid · ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate +2 moreEnzymes: Vesicular inhibitory amino acid transporter, Gamma-aminobutyric acid type B receptor subunit 2Tolfenamic acid Action Pathway
smpdb.ca/view/SMP0126549Drug actionThe inhibition of both COX-1 and COX-2 by tolfenamic acid reduces the formation of prostaglandin H2 and therefore, prostaglandin E2 (PGE2). … Tolfenamic acid is a nonsteroidal anti-inflammatory agent (NSAID) used to treat pain associated with the acute attack of migraine in adults.
Acetohydroxamic acid Drug Metabolism
smpdb.ca/view/SMP0130492MetabolicAcetohydroxamic acid passes through the liver and is then excreted from the body mainly through the kidney. … Acetohydroxamic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Acetohydroxamic acidEtidronic acid Drug Metabolism
smpdb.ca/view/SMP0130677MetabolicEtidronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Etidronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Etidronic acidMedronic acid Drug Metabolism
smpdb.ca/view/SMP0130690MetabolicMedronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Medronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Medronic acidAlendronic acid Drug Metabolism
smpdb.ca/view/SMP0130694MetabolicAlendronic acid passes through the liver and is then excreted from the body mainly through the kidney. … Alendronic acid is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.
Drugs: Alendronic acidGlutaminolysis and Cancer
smpdb.ca/view/SMP0002298DiseaseThe oxoglutaric acid can also be transformed into citric acid which then gets turned into acetyl coa and get incorporated into the lipid synthesis … Once it reaches malic acid, it is transported outside the mitochondria and transformed into pyruvic acid and lactate.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Succinic acid +9 moreEnzymes: Y+L amino acid transporter 1, Neutral amino acid transporter ANicotinate and Nicotinamide Metabolism
smpdb.ca/view/SMP0000048MetabolicThese compounds can be found in the diet, where the mixture of nicotinic acid and nicotinamide are called vitamin B3 or niacin. … and plants.