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Sodium- and chloride-dependent glycine transporter 2
go.drugbank.com/bio_entities/BE0002310TransporterTargetHumansSodium- and chloride-dependent glycine transporter (PubMed:10381548, PubMed:10606742, PubMed:16751771, PubMed:31370103, PubMed:9845349).
Polypeptides: Sodium- and chloride-dependent glycine transporter 2Signal transducer and activator of transcription 3
go.drugbank.com/bio_entities/BE0003462TargetHumansand IL6ST) (PubMed:9188471) … Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity
Polypeptides: Signal transducer and activator of transcription 3Disintegrin and metalloproteinase domain-containing protein 17
go.drugbank.com/bio_entities/BE0003754TargetHumansMediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. … and immunity (PubMed:24226769, PubMed:24227843, PubMed:28060820, PubMed:28923481, PubMed:38771644).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 17Macrophage scavenger receptor types I and II
go.drugbank.com/bio_entities/BE0010942TargetHumansRecognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation … Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate
Polypeptides: Macrophage scavenger receptor types I and IISynonyms: Macrophage acetylated LDL receptor I and IICleavage and polyadenylation specificity factor subunit 3
go.drugbank.com/bio_entities/BE0021153TargetHumansand other factors to bring about cleavage and poly(A) addition. … Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (By similarity)
Polypeptides: Cleavage and polyadenylation specificity factor subunit 3Synonyms: Cleavage and polyadenylation specificity factor 73 kDa subunitMultifunctional procollagen lysine hydroxylase and glycosyltransferase LH3
go.drugbank.com/bio_entities/BE0002195TargetEnzymeHumansCatalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:25419660). … Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed:18834968). Essential for normal formation of basement membranes (By similarity)
Polypeptides: Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3Disintegrin and metalloproteinase domain-containing protein 9
go.drugbank.com/bio_entities/BE0003412TargetHumansMetalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. … May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 9Function: collagen bindingSodium- and chloride-dependent GABA transporter 3
go.drugbank.com/bio_entities/BE0004733TargetHumansCan also mediate transport of beta-alanine and to a lower extent that of taurine and hypotaurine (By similarity) … Mediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:7874447).
Polypeptides: Sodium- and chloride-dependent GABA transporter 3Disintegrin and metalloproteinase domain-containing protein 33
go.drugbank.com/bio_entities/BE0019245TargetHumansMetalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed … Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways (PubMed:33982767).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 33NACHT, LRR and PYD domains-containing protein 3
go.drugbank.com/bio_entities/BE0010347TargetHumansRecruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD … Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis
Polypeptides: NACHT, LRR and PYD domains-containing protein 3