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Moclobemide Amine Oxidase Norepinephrine Antidepressant Action Pathway
smpdb.ca/view/SMP0126685Drug actionMoclobemide is a reversible monoamine oxidase inhibitor (MAOIs) selective for the isoform A (RIMA). This molecule is indicated in the treatment of major depressive disorder (MDD) and bipolar disorder. he monoamine oxidase is an enzyme th...
Enzymes: Sodium-dependent noradrenaline transporterNelarabine Action Pathway
smpdb.ca/view/SMP0126649Drug actionNelarabine is an antineoplastic agent from the nucleoside analog drug class. This drug is indicated in the treatment of T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymp...
Enzymes: Sodium/nucleoside cotransporter 2Duloxetine (SNRI) - Norepinephrine Reuptake Inhibiton
smpdb.ca/view/SMP0125000Drug actionIt blocks both sodium dependent serotonin and sodium dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic cleft.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Duloxetine · Dopamine +4 moreEnzymes: Sodium-dependent noradrenaline transporterAtomoxetine Action Pathway (New)
smpdb.ca/view/SMP0126353Drug actionAtomoxetine binds to the sodium-dependent noradrenaline transporter, this prevents the noradrenaline reuptake in the presynaptic neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Atomoxetine · Sapropterin · Norepinephrine +5 moreEnzymes: Sodium-dependent noradrenaline transporterCocaine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126544Drug actionCocaine inhibits the sodium-dependent noradrenaline channel which causes norepinephrine to accumulate in the synapse.
Enzymes: Sodium-dependent noradrenaline transporterBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionDopamine is released into the synapse where it is much more difficult for it to re-enter the presynaptic neuron due to bupropion inhibiting the sodium-dependent dopamine receptor. … Norepinephrine is released into the synapse where it accumulates because bupropion is weakly inhibiting the sodium-dependent noradrenaline receptor which prevents norepinephrine from re-entering the presynaptic
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterSolriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionThose transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain.
Enzymes: Sodium-dependent dopamine transporter, Sodium-dependent noradrenaline transporterNorepinephrine Neurological
smpdb.ca/view/SMP0130946PhysiologicalNorepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as both a hormone and neurotransmitter. The name "noradrenaline" (from Latin ad,...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +3 moreEnzymes: Sodium-dependent noradrenaline transporterGABA-Transaminase Deficiency
smpdb.ca/view/SMP0000351DiseaseGABA-transaminase deficiency, also known as gamma-amino butyric acid transaminase (GABA-T) deficiency, is an extremely rare autosomal recessive inborn error of metabolism (IEM) that is caused by a defect in the ABAT gene, which codes for...
Enzymes: Sodium-coupled neutral amino acid transporter 4Carnosinuria, Carnosinemia
smpdb.ca/view/SMP0000493DiseaseCarnosinemia, also known as carnosinemia, is a rare inborn error of metabolism (IEM) and recessive autosomal disorder caused by a defective CNDP1 gene which encodes for carnosinase. Carnosinase is a dipeptidase enzyme that catalyzes the ...
Enzymes: Sodium-coupled neutral amino acid transporter 4