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Lesch-Nyhan Syndrome (LNS)
smpdb.ca/view/SMP0000364DiseaseIt is characterized by a mental deficit and self-mutilation, accompanied with an overproduction of uric acid. … Patients are usually unable to walk, and the connection between a lack of hypoxanthine phosphoribosyltransferase 1 and the behavioural abnormalities associated with this condition are unknown.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreThioguanine Action Pathway (old)
smpdb.ca/view/SMP0000430Drug actionThioguanine is a purine antimetabolite prodrug closely related to mercaptopurine and similarly inhibits purine metabolism. The thioguanine pathway is shown as a part of the mercaptopurine pathway. Thioguanine exerts cytotoxic effects via...
Drugs: Tetrahydrofolic acid · Ademetionine · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid +27 moreMitochondrial DNA Depletion Syndrome-3
smpdb.ca/view/SMP0000536DiseaseSymptoms of DGUOK deficiency can arise in the form of a multi-system disease in neonates or an isolated hepatic disease in infancy, with the former being more common.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreMyoadenylate Deaminase Deficiency
smpdb.ca/view/SMP0000537DiseaseTreatment with methotrexate is very effective. It is estimated that <disease name> affects 1 in 50 to 100 people in white population and affecting African American 1 in 40,000 people.
Drugs: Tetrahydrofolic acid · Aspartic acid · L-Glutamine · Adenosine phosphate · Glutamic acid · Glycine +24 moreHomocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type
smpdb.ca/view/SMP0000570DiseaseTreatment with vitamin B12, as well as folates and betaine is effective. It is estimated that methionine synthase deficiency affects less than 1 in 1,000,000 individuals.
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 moreSalicylate-Sodium Action Pathway
smpdb.ca/view/SMP0000708Drug actionSalicylate-sodium (also named salsonin or clin) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used for relieving pain and reducing fever. Salicylate-sodium can block prostaglandin synthesis by the action of inhibition of pr...
Drugs: Glutamic acid · Glutathione · Dinoprostone · Calcium · Magnesium cation · Salicylic acid +5 moreDipyridamole Action Pathway
smpdb.ca/view/SMP0122804Drug actionDipyridamole is an oral coronary vasodilator and antiplatelet drug used in combination with other anti-coagulant drugs to prevent thrombosis in patients with valvular and vascular disorders.
Salicylic Acid COX Action Pathway
smpdb.ca/view/SMP0124590Drug actionThe cyclooxygenase pathway begins in the cytosol with phospholipids being converted into arachidonic acid by the action of phospholipase A2.
Metabolism and Physiological Effects of Xanthosine
smpdb.ca/view/SMP0124866MetabolicAdenosine then reacts with water to form inosine and ammonia using the enzyme adenosine deaminase. Inosine goes on to form hypoxanthine through the enzyme purine nucleoside phosphorylase.
Cystathionine beta-Synthase Deficiency
smpdb.ca/view/SMP0125678DiseaseCystathionine Beta-Synthase Deficiency (CBS Deficiency; Homocystinuria) is an autosomal recessive disease caused by a mutation in the CBS gene which codes for cystathionine beta-synthase. A deficiency in this enzyme results in accumulati...
Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Choline · Adenosine phosphate · Serine +17 more