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Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
go.drugbank.com/bio_entities/BE0003094TargetHumansThe first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate
Polypeptides: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1POU domain, class 5, transcription factor 1
go.drugbank.com/bio_entities/BE0003665TransporterTargetHumansTranscription factor that binds to the octamer motif (5'-ATTTGCAT-3').
Polypeptides: POU domain, class 5, transcription factor 12,3-diketo-5-methylthiopentyl-1-phosphate enolase
go.drugbank.com/bio_entities/BE0003741TargetGeobacillus kaustophilus (strain HTA426)Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
Polypeptides: 2,3-diketo-5-methylthiopentyl-1-phosphate enolaseFunction: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activityType II inositol 1,4,5-trisphosphate 5-phosphatase
go.drugbank.com/bio_entities/BE0004437TargetHumansAlso hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events … Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P.
Polypeptides: Type II inositol 1,4,5-trisphosphate 5-phosphataseSynonyms: Phosphoinositide 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphataseInsulin-like growth factor-binding protein 5
go.drugbank.com/bio_entities/BE0009661CarrierHumansMultifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type spe...
Polypeptides: Insulin-like growth factor-binding protein 5Synonyms: IBP-5, IGFBP-5Sodium channel protein type 5 subunit alpha
go.drugbank.com/bio_entities/BE0000197TargetHumansPore-forming subunit of Nav1.5, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes (PubMed:33712541, PubMed:40768348). Navs, also called VGSCs (voltage-gated sod...
Polypeptides: Sodium channel protein type 5 subunit alphaTumor necrosis factor receptor superfamily member 5
go.drugbank.com/bio_entities/BE0001196TargetHumansReceptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
Polypeptides: Tumor necrosis factor receptor superfamily member 5cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
go.drugbank.com/bio_entities/BE0001223TargetHumansCyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibitin...
Polypeptides: cGMP-inhibited 3',5'-cyclic phosphodiesterase 3BFunction: 3',5'-cyclic-AMP phosphodiesterase activityIntracellular exo-alpha-(1->5)-L-arabinofuranosidase
go.drugbank.com/bio_entities/BE0001766TargetGeobacillus stearothermophilusCatalyzes the cleavage of terminal alpha-(1->5)-arabinofuranosyl bonds in different hemicellulosic homopolysaccharides (branched and debranched arabinans).
Polypeptides: Intracellular exo-alpha-(1->5)-L-arabinofuranosidaseSynonyms: Intracellular arabinan exo-alpha-(1->5)-L-arabinosidaseNAD-dependent protein deacylase sirtuin-5, mitochondrial
go.drugbank.com/bio_entities/BE0003362TargetHumansNAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 an...
Polypeptides: NAD-dependent protein deacylase sirtuin-5, mitochondrialSynonyms: SIR2-like protein 5, Regulatory protein SIR2 homolog 5