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Displaying results 4211 - 4220 of 10000 in total
  1. Drug

    Doxorubicin

    go.drugbank.com/drugs/DB00997
    ApprovedInvestigational

    Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970. … [A257614] Thanks to its efficacy and broad effect, doxorubicin was approved by the FDA in 1974 to treat a variety of cancer, including but not limited to breast, lung, gastric, ovarian, thyroid, non-Hodgkin

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: (1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside, (8S-cis)-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
  2. Target

    Glucose-6-phosphate 1-dehydrogenase

    go.drugbank.com/bio_entities/BE0001439
    TargetLeuconostoc mesenteroides

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone. Can utilize either NADP(+) or NAD(+).

    Polypeptides: Glucose-6-phosphate 1-dehydrogenaseSynonyms: Glucose-6-phosphate dehydrogenase (NAD(P)(+))
  3. Target

    Glucosamine-6-phosphate deaminase 1

    go.drugbank.com/bio_entities/BE0001567
    TargetHumans

    Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine

    Polypeptides: Glucosamine-6-phosphate deaminase 1Synonyms: Glucosamine-6-phosphate isomerase 1
  4. Target

    Glucosamine-6-phosphate deaminase 1

    go.drugbank.com/bio_entities/BE0001752
    TargetBacillus subtilis (strain 168)

    Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.

    Polypeptides: Glucosamine-6-phosphate deaminase 1Synonyms: Glucosamine-6-phosphate isomerase 1
  5. Target

    Protein-glutamine gamma-glutamyltransferase 6

    go.drugbank.com/bio_entities/BE0002239
    EnzymeHumans

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins

    Polypeptides: Protein-glutamine gamma-glutamyltransferase 6Synonyms: TGase-6, Transglutaminase-6
  6. Target

    rRNA adenine N-6-methyltransferase

    go.drugbank.com/bio_entities/BE0002516
    TargetBacillus subtilis

    This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.

    Polypeptides: rRNA adenine N-6-methyltransferaseFunction: 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
  7. Target

    Programmed cell death protein 6

    go.drugbank.com/bio_entities/BE0005812
    TargetHumans

    Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protei...

    Polypeptides: Programmed cell death protein 6
  8. Target

    Ephrin type-A receptor 6

    go.drugbank.com/bio_entities/BE0009439
    TargetHumans

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the rece...

    Polypeptides: Ephrin type-A receptor 6
  9. Target

    Interleukin-6 receptor subunit beta

    go.drugbank.com/bio_entities/BE0010013
    TargetHumans

    Engages site 2 of CNTF, CLCF1, LIF, and IL-6, and site 3 of IL27 and IL6 (PubMed:36930708). … In contrast, binding of other IL-6 family cytokines can result in the formation of a IL6ST/gp130 heterodimer with another signal-transducing receptor, such as LIFR or OSMR (PubMed:1542794, PubMed:39532904

    Polypeptides: Interleukin-6 receptor subunit betaSynonyms: IL-6 receptor subunit beta, Interleukin-6 signal transducer
  10. Target

    TNF receptor-associated factor 6

    go.drugbank.com/bio_entities/BE0021309
    TargetHumans

    E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:1946591...

    Polypeptides: TNF receptor-associated factor 6