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Displaying results 4601 - 4610 of 10000 in total
  1. Target

    tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase

    go.drugbank.com/bio_entities/BE0002518
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

    Polypeptides: tRNA (cytidine(34)/5-carboxymethylaminomethyluridine(34)-2'-O)-methyltransferase
  2. Target

    High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

    go.drugbank.com/bio_entities/BE0003134
    TargetHumans

    Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity...

    Polypeptides: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AFunction: 3',5'-cyclic-AMP phosphodiesterase activity
  3. Target

    Leucine-rich repeat-containing G protein-coupled receptor 5

    go.drugbank.com/bio_entities/BE0010835
    TargetHumans

    Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with ph...

    Polypeptides: Leucine-rich repeat-containing G protein-coupled receptor 5
  4. Target

    Transient receptor potential cation channel subfamily M member 5

    go.drugbank.com/bio_entities/BE0020643
    TargetHumans

    Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated di...

    Polypeptides: Transient receptor potential cation channel subfamily M member 5Synonyms: LTrpC-5, Long transient receptor potential channel 5
  5. Drug

    Potassium nitrate

    go.drugbank.com/drugs/DB11090
    ApprovedInvestigational

    In addition, potassium nitrate is used as a diuretic in pigs, cattle, and horses. It is administered orally doses up to 30 g per animal per day [L1736]. … It is a natural source of nitrate and has been used as a constituent for several different purposes, including food preservatives, fertilizers, tree stump removal, rocket propellants, and fireworks.

    Mixtures: Grafco Applicator 15 Cm, Kiss My Face Enamel ExtraCategories: Compounds used in a research, industrial, or household setting
  6. Drug

    Selexipag

    go.drugbank.com/drugs/DB11362
    ApprovedInvestigational

    PAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes.

    Categories: Heterocyclic Compounds, 1-Ring, P-glycoprotein substratesProducts: UPTRAVI 200 MCG FILM KAPLI TABLET, 140 ADET, SELPENZA 200 MCG FİLM KAPLI TABLET, 140 ADET
  7. Drug

    Fosamprenavir

    go.drugbank.com/drugs/DB01319
    ApprovedInvestigational

    Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: TELZIR 700 MG FİLM KAPLI TABLET, 60 ADET, TELZIR®
  8. Drug

    Probenecid

    go.drugbank.com/drugs/DB01032
    ApprovedInvestigational

    It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. … Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

    Synonyms: 4-(N,N-Dipropylsulfamoyl)benzoesäure, 4-(Di-n-propylsulfamoyl)benzoesäureCategories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 CYP3A Inducers
  9. Drug

    Arbutin

    go.drugbank.com/drugs/DB11217
    Approved

    It has also been used as an anti-infective for the urinary system as well as a diuretic [F43]. … Arbutin is a competitive inhibitor of tyrosinase (E.C.1.14.18.1) in melanocytes [A27248], and the inhibition of melanin synthesis at non-toxic concentrations was observed _in vitro_.

    Synonyms: hydroquinone O-β-D-glucopyranoside, p-hydroxyphenyl β-D-glucosideMixtures: Dr G Whitening REFORMER by EGF, Dr G Whitening FORTIFIER by EGF
  10. Pathway

    Acylcarnitine 10-Hydroxydodec-3-enedioylcarnitine

    smpdb.ca/view/SMP0124027
    Metabolic

    10-Hydroxydodec-3-enedioylcarnitine is an acylcarnitine. … In forming an acylcarnitine derivative, 10-hydroxydodec-3-enedioyl-CoA reacts with L-carnitine to form 10-hydroxydodec-3-enedioylcarnitine.

    Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more
    Enzymes: Solute carrier family 22 member 5