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Bendamustine
go.drugbank.com/drugs/DB06769ApprovedInvestigationalThrough this function as an alkylating agent, bendamustine causes intra- and inter-strand crosslinks between DNA bases resulting in cell death. … It is active against both active and quiescent cells, although the exact mechanism of action is unknown.
Categories: Antineoplastic and Immunomodulating AgentsProducts: RIBOMUSTIN 25MG/VIAL POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION, BENDAMUS 25MG IV INFÜZYON IÇIN LIYOFILIZE TOZ IÇEREN FLAKON, FLAKON, 1 ADETValine, Leucine, and Isoleucine Degradation
smpdb.ca/view/SMP0000032MetabolicIsovaleryl-CoA is produced from leucine by these two reactions, alpha-methylbutyryl-CoA from isoleucine, and isobutyryl-CoA from valine. … These acyl-CoA’s undergo dehydrogenation, catalyzed by three different but related enzymes, and the breakdown pathways then diverge.
Threonine and 2-Oxobutanoate Degradation
smpdb.ca/view/SMP0000452MetabolicE3 then transfers protons to NAD in order to restore the lipoate. … 2-oxobutanoate, also known as 2-Ketobutyric acid, is a 2-keto acid that is commonly produced in the metabolism of amino acids such as methionine and threonine.
Fluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalThese drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Mixtures: FLUTIFORM 250/10UG 120 HUB, FLUTIFORM 250/10UG 3X120HUProducts: Up and Up Allergy Relief Nasal, Up and Up allergy relief nasalIvermectin
go.drugbank.com/drugs/DB00602ApprovedInvestigationalVet approvedIvermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly-active broad-spectrum antiparasitic agents isolated from the fermentation products of _Streptomyces avermitilis … [L31453] Ivermectin is mainly used in humans in the treatment of onchocerciasis, but may also be effective against other worm infestations (such as strongyloidiasis, ascariasis, trichuriasis and enterobiasis
Mixtures: Heartgard Plus Chewable Tablet for Dogs - Up to 25 lbsCategories: Scabicides and Pediculicides, Antiparasitic Products, Insecticides and RepellentsExenatide
go.drugbank.com/drugs/DB01276ApprovedInvestigationalIt activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control[L42690]. … It is available as immediate- and extended-release formulations.[L42685,L42690] Bydureon, the brand name product of extended-release exenatide in an injectable suspension, was discontinued in 2021.
Categories: Fluids and Secretions, Alimentary Tract and MetabolismProducts: BYDUREON POWDER AND SOLVENT FOR PROLONGED-RELEASE SUSPENSION FOR INJECTION IN PRE-FILLED PEN 2MG, BYDUREON 2 mg powder and solvent for prolonged-release suspension for injectionTamoxifen
go.drugbank.com/drugs/DB00675ApprovedInvestigational[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments. … [L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].
Categories: Antineoplastic and Immunomodulating Agents, Hormone Antagonists and Related AgentsProducts: Tamone Tab 10mg, Tamone Tab 20mgEstriol
go.drugbank.com/drugs/DB04573ApprovedInvestigationalVet approvedIt has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes. … A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen.
Categories: Genito Urinary System and Sex Hormones, Natural and Semisynthetic Estrogens, PlainProducts: OEKOLP TABLETTEN 2MG, ESTRIOL 2MG FEM JENAPHARMSelenium Sulfide
go.drugbank.com/drugs/DB00971ApprovedSelenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. … Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent
Mixtures: Clease and TreatProducts: Head and Shoulders Itch, Walgreens Dandruff and Conditioner Cleansing and Conditioning Anti-dandruffCisatracurium
go.drugbank.com/drugs/DB00565ApprovedInvestigational[A243416,A253592] Cisatracurium is an R-cis-R-cis isomer of [atracurium] and has approximately 3 times its neuromuscular blocking potency. … [A243416,A253592] Cisatracurium has an intermediate duration of action and is one of the most commonly used neuromuscular blocking agents in intensive care.[A253592,A253597].
Products: Nimbex 10mg/ml, KABICURIUM® 10MG/5ML