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Displaying results 481 - 490 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of Kynurenine

    smpdb.ca/view/SMP0125524
    Disease

    Kynurenine is naturally synthesized in the body from tryptophan. Tryptophan is consumed through foods such as milk, eggs, chicken, turkey, and oats. … Tryptophan is then transported from the small intestine into the blood by an amino acid transport.

    Drugs: Tryptophan · Formic acid · Kynurenine · Mesoheme
    Enzymes: Neutral and basic amino acid transport protein rBAT
  2. Pathway

    Metabolism and Physiological Effects of Isovalerylglycine

    smpdb.ca/view/SMP0126748
    Metabolic

    its isomer, pivaloylcarnitine; pivaloylcarnitine is derived from pivalate-generating antibiotics, and has caused many false-positive results. … important to caution for false positive results when screening for isovaleric acidemia by tandem mass spectrometry based on dried blood-spot levels of C5-acylcarnitines, including isovalerylcarnitine and

    Drugs: Glycine · Proline
  3. Pathway

    Metabolism and Physiological Effects of Tiglylglycine

    smpdb.ca/view/SMP0126840
    Metabolic

    Tiglylglycine is an intermediate product of the catabolism of isoleucine. … An elevated level of tiglylglycine is identified in urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism.

    Drugs: Glutamic acid · Glycine · Isoleucine · Oxogluric acid · Flavin adenine dinucleotide
  4. Pathway

    Metabolism and Physiological Effects of Citrulline

    smpdb.ca/view/SMP0126861
    Metabolic

    Ornithine transcarbamoylase (OTC) or OCT (EC 2.1. 3.3) is an enzyme that catalyzes the reaction of citrulline formation from l-ornithine and carbamoyl phosphate. … In particular, citrulline can be biosynthesized from carbamoyl phosphate and ornithine which is catalyzed by the enzyme ornithine carbamoyltransferase.

    Drugs: Ornithine · Glycine · Citrulline
  5. Drug

    Pembrolizumab

    go.drugbank.com/drugs/DB09037
    ApprovedInvestigational

    [F136] It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014,[L2954] becoming the first approved therapy against PD-1. … [A18829] It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: KEYTRUDA SOLUTION FOR INFUSION 25MG/ML, Keytruda 100mg Solution for Infusion
  6. Pathway

    Metabolism and Physiological Effects of Putrescine

    smpdb.ca/view/SMP0123276
    Metabolic

    Like other polyamines such as spermidine and spermine, putrescine can also be obtained directly from diet as well. … Putrescine is an aliphatic amine that is formed through gut microbial metabolism from the amino acid arginine which is acquired from foods that are high in protein.

    Drugs: Arginine · Ornithine · Putrescine · Urea
  7. Pathway

    Metabolism and Physiological Effects of Xanthosine

    smpdb.ca/view/SMP0124866
    Metabolic

    Xanthosine is formed from purine catabolism. Purines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. … Xanthine is formed from hypoxanthine using the enzyme xanthine dehydrogenase/ oxidase. Xanthine can also be formed from the purine guanine via guanine deaminase.

    Drugs: Adenine · Adenosine · Zinc · Xanthine · Guanine · Ribose-1-Phosphate +3 more
  8. Pathway

    Metabolism and Physiological Effects of Uridine

    smpdb.ca/view/SMP0124871
    Metabolic

    More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. … L-glutamine is first converted to carbamoyl phosphate then to N-Carbamoyl-L-aspartate and finally to dihydroorotate by the CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and

    Drugs: Aspartic acid · L-Glutamine · ATP · Magnesium cation · Zinc · Uridine +3 more
  9. Drug

    Docetaxel

    go.drugbank.com/drugs/DB01248
    ApprovedInvestigational

    [A259676] Compared to paclitaxel, docetaxel is two times more potent as an inhibitor of microtubule depolymerization. Docetaxel binds to microtubules but does not interact with dimeric tubulin. … [L46466] Docetaxel was approved by the FDA in 1996 and is available in solution for injection for intravenous or parenteral administration.[A259676]

    Categories: Antineoplastic and Immunomodulating AgentsProducts: Oncotaxel Concentrate and solvent for solution for infusion 40 mg/ ml, Docel Docetaxel Injection 10mg/mL
  10. Drug

    Lorlatinib

    go.drugbank.com/drugs/DB12130
    ApprovedInvestigational

    It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to … Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer[L39905] which was first approved by the US FDA in November of 2018

    Categories: Antineoplastic and Immunomodulating AgentsProducts: LORVIQUA FILM-COATED TABLET 25MG, LORVIQUA FILM-COATED TABLET 100MG