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Miconazole
go.drugbank.com/drugs/DB01110ApprovedInvestigationalVet approved[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream. … [A203636] It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams
Mixtures: Vobaderm 1mg/g + 20mg/g Creme, Up and Up Miconazole 1Categories: Imidazole and Triazole Derivatives, Vaginal Creams, Foams, and JelliesPembrolizumab
go.drugbank.com/drugs/DB09037ApprovedInvestigational[F136] It was developed by Merck & Co and first approved for the treatment of metastatic malignant melanoma by the FDA on September 4, 2014,[L2954] becoming the first approved therapy against PD-1. … [A18829] It contains 32 cysteine residues and the complete folded molecule includes 4 disulfide linkages as interchain bonds and 23 interchain bonds.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: KEYTRUDA SOLUTION FOR INFUSION 25MG/ML, Keytruda 100mg Solution for InfusionNitroglycerin
go.drugbank.com/drugs/DB00727ApprovedInvestigational[A180166,A180172] Its use as a treatment for angina dates back to 1879 and is still used to treat and prevent angina.[A249970] Nitroglycerin causes vasodilation in both arteries and veins. … failure,[L7099] and chronic anal fissure.
Categories: Nitrates and Nitrites, Agents for Treatment of Hemorrhoids and Anal Fissures for Topical UseSynonyms: NGMoclobemide
go.drugbank.com/drugs/DB01171ApprovedInvestigationalDue to negligible anticholinergic and antihistaminic actions, moclobemide has been better tolerated than tri- or heterocyclic antidepressants [A31901]. … Most meta-analyses and most studies indicate that in the acute management of depression, moclobemide is more efficacious than placebo medication and similarly efficacious as tricyclic antidepressants (
Synonyms: 4-Chlor-N-(2-morpholinoethyl)benzamid, p-Chloro-N-(2-morpholinoethyl)benzamideCategories: Benzamides and benzamide derivatives, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeIndapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigational[A204155] Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. … [A204134,A204161] Indapamide is characterized by both a methylindoline and a sulfamoyl chlorobenzamide functional group, with the former being largely responsible for the molecule’s lipid solubility
Mixtures: COVERSYL PLUS Tablet 10mg/2.5mg, COVERSYL PLUS 10MG/2.5MG FILM-COATED TABLETCategories: Non Potassium Sparing Diuretics, Genito Urinary System and Sex HormonesCarbimazole
go.drugbank.com/drugs/DB00389ApprovedAn imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Categories: Sex Hormones and Insulins, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: NEO MERCAZOLE, CARBIMAZOL 10MG HENNINGD-Arginine and D-Ornithine Metabolism
smpdb.ca/view/SMP0000036MetabolicD-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions. … DAAO is highly specific towards D-amino acids and favours free neutral D-amino acids or those with hydrophobic, polar or aromatic groups. Acidic amino acids are not catalyze by DAOO.
Metabolism and Physiological Effects of Phenylacetylglutamine
smpdb.ca/view/SMP0123208MetabolicPhenylacetylglutamine is a normal constituent of human urine, but other mammals such as the dog, cat, rat, monkey, sheep, and horse do not excrete this compound. … Phenylacetyl-CoA and L-glutamine react to form phenylacetylglutamine and coenzyme A.
Drugs: Phenylalanine · L-Glutamine · Adenosine phosphate · ATP · Magnesium cation · Phenylpyruvic acid +1 moreMetabolism and Physiological Effects of Phenol
smpdb.ca/view/SMP0123255MetabolicPhenol is shown to cause cardiovascular disease and enhance the production of reactive oxygen species and cause oxidative stress. … Phenol can get further metabolized in a liver hepatocyte to Phenyl sulphate and Phenyl glucuronide. However phenol itself is shown to be a major uremic toxin through high levels of retention.
Metabolism and Physiological Effects of Choline
smpdb.ca/view/SMP0124739MetabolicCholine is obtained from foods like poultry, meat, fish, dairy and eggs. … TMAO has negative effects on organs such as the heart, kidney and vascular system by contributing to cardiovascular disease, atherosclerosis, endothelial dysfunction and kidney disease.