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Adenosine 5'-monophosphoramidase HINT1
go.drugbank.com/bio_entities/BE0001473TargetEnzymeHumansModulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:19112177). … In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed:16014379, PubMed:22647378)
Synonyms: Protein kinase C-interacting protein 1, Protein kinase C inhibitor 1Heat shock protein HSP 90-beta
go.drugbank.com/bio_entities/BE0001898TargetHumansEngages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the … Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone.
Polypeptides: Heat shock protein HSP 90-betaSynonyms: Heat shock protein family C member 3Receptor tyrosine-protein kinase erbB-4
go.drugbank.com/bio_entities/BE0004772TargetHumansRequired for mammary gland differentiation, induction of milk proteins and lactation. … The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation.
Polypeptides: Receptor tyrosine-protein kinase erbB-4Synonyms: Proto-oncogene-like protein c-ErbB-4Oligodendrocyte transcription factor 2
go.drugbank.com/bio_entities/BE0014194TargetHumansRequired for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Works in coordination with ZNF488 to promote oligodendrocyte differentiation. Orche...
Synonyms: Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17Receptor tyrosine-protein kinase erbB-3
go.drugbank.com/bio_entities/BE0009917TargetHumansTyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation (PubMed:9148746, PubMed:20351256). Functions primarily as a heterodimer...
Polypeptides: Receptor tyrosine-protein kinase erbB-3Synonyms: Proto-oncogene-like protein c-ErbB-3Heat shock protein HSP 90-alpha
go.drugbank.com/bio_entities/BE0001120TargetHumansEngages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the … Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone.
Polypeptides: Heat shock protein HSP 90-alphaSynonyms: Heat shock protein family C member 1, LPS-associated protein 2Heat shock protein 75 kDa, mitochondrial
go.drugbank.com/bio_entities/BE0014134TargetHumansChaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the bala...
Polypeptides: Heat shock protein 75 kDa, mitochondrialSynonyms: Heat shock protein family C member 5, TNFR-associated protein 1Lysyl oxidase homolog 4
go.drugbank.com/bio_entities/BE0018464TargetHumansCatalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers
Synonyms: Lysyl oxidase-related protein C, Lysyl oxidase-like protein 4Plasma serine protease inhibitor
go.drugbank.com/bio_entities/BE0002112TargetHumansActs as a procoagulant and pro-inflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex … Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the
Synonyms: Protein C inhibitorBeta-2-glycoprotein 1
go.drugbank.com/bio_entities/BE0002854TargetHumansBinds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells
Synonyms: Activated protein C-binding proteinFunction: identical protein binding