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Displaying results 41 - 50 of 296 in total
  1. Target

    Sodium/myo-inositol cotransporter 2

    go.drugbank.com/bio_entities/BE0017647
    TransporterHumans

    Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932). … Exhibits stereospecific cotransport of both D-glucose and D-xylose (By similarity). May induce apoptosis through the TNF, PDCD1 pathway (PubMed:15172003, PubMed:18069935).

    Polypeptides: Sodium/myo-inositol cotransporter 2Synonyms: Sodium/glucose cotransporter KST1, Sodium/myo-inositol transporter 2
  2. Target

    Epithelial sodium channel subunit alpha

    go.drugbank.com/bio_entities/BE0000190
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247).

    Polypeptides: Epithelial sodium channel subunit alphaSynonyms: Amiloride-sensitive sodium channel subunit alpha, Sodium channel epithelial 1 subunit alpha
  3. Target

    Epithelial sodium channel subunit gamma

    go.drugbank.com/bio_entities/BE0000497
    TargetTransporterHumans

    This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247, PubMed:7550319, PubMed:8640238).

    Polypeptides: Epithelial sodium channel subunit gammaSynonyms: Amiloride-sensitive sodium channel subunit gamma, Sodium channel epithelial 1 subunit gamma
  4. Target

    Ileal sodium/bile acid cotransporter

    go.drugbank.com/bio_entities/BE0003643
    TransporterTargetHumans

    Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:7592981, PubMed:9458785, PubMed:9856990). … Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:7592981, PubMed:9458785, PubMed:9856990).

    Polypeptides: Ileal sodium/bile acid cotransporterSynonyms: Apical sodium-dependent bile acid transporter, Ileal sodium-dependent bile acid transporter
  5. Target

    Electrogenic sodium bicarbonate cotransporter 1

    go.drugbank.com/bio_entities/BE0004675
    TransporterTargetHumans

    Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. … May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH

    Polypeptides: Electrogenic sodium bicarbonate cotransporter 1Synonyms: Sodium bicarbonate cotransporter
  6. Target

    Electrogenic sodium bicarbonate cotransporter 4

    go.drugbank.com/bio_entities/BE0004677
    TransporterHumans

    Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3

    Polypeptides: Electrogenic sodium bicarbonate cotransporter 4
  7. Target

    Electroneutral sodium bicarbonate exchanger 1

    go.drugbank.com/bio_entities/BE0004680
    TransporterTargetHumans

    Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). … Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)

    Polypeptides: Electroneutral sodium bicarbonate exchanger 1
  8. Target

    Sodium-dependent lysophosphatidylcholine symporter 1

    go.drugbank.com/bio_entities/BE0016969
    TransporterHumans

    Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:32572202, PubMed:34135507). … Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters

    Polypeptides: Sodium-dependent lysophosphatidylcholine symporter 1Synonyms: Sodium-dependent LPC symporter 1
  9. Target

    V-type sodium ATPase subunit K

    go.drugbank.com/bio_entities/BE0001440
    TargetEnterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258)

    Involved in ATP-driven sodium extrusion.

    Polypeptides: V-type sodium ATPase subunit KSynonyms: Sodium ATPase proteolipid component
  10. Target

    Sodium channel regulatory subunit beta-4

    go.drugbank.com/bio_entities/BE0003638
    TargetHumans

    Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across … Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes.

    Polypeptides: Sodium channel regulatory subunit beta-4Function: sodium channel regulator activity