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Tyrosine-protein phosphatase non-receptor type 2
go.drugbank.com/bio_entities/BE0012706TargetHumansNegatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream
Polypeptides: Tyrosine-protein phosphatase non-receptor type 2Dual specificity tyrosine-phosphorylation-regulated kinase 2
go.drugbank.com/bio_entities/BE0017531TargetHumansSerine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth (PubMed:11311121, PubMed:12588975, PubMed:16511445, PubMed:166116...
Polypeptides: Dual specificity tyrosine-phosphorylation-regulated kinase 2Cyproterone acetate
go.drugbank.com/drugs/DB04839ApprovedInvestigationalIt is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Mixtures: DONABELLA® 2 MG /0.035 MG, DONABELLA® 2 MG /0.035 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigationalOriginally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.
Synonyms: (1Z)-1(2H)-Phthalazinone hydrazone, Hydrazone 1(2H)-phthalazinoneInternational brands: Cesoline W, Cesoline Y2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
go.drugbank.com/bio_entities/BE0001450TargetEscherichia coli (strain K12)Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
Polypeptides: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseFunction: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activityGamma-aminobutyric acid receptor subunit beta-2
go.drugbank.com/bio_entities/BE0002346TargetHumansGABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, … Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-2Synonyms: GABAAR subunit beta-2, GABA(A) receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2
go.drugbank.com/bio_entities/BE0003592TargetHumansGABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:23909897, … Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity).
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-2Synonyms: GABAAR subunit gamma-2, GABA(A) receptor subunit gamma-2Gamma-aminobutyric acid receptor subunit rho-2
go.drugbank.com/bio_entities/BE0003598TargetHumansRho-2 GABAARs expressed in retina may play a role in retinal neurotransmission (By similarity) … Rho-2 GABAARs may contribute to the regulation of glial development in the cerebellum by controlling extrasynaptic transmission.
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Synonyms: GABAAR subunit rho-2, GABA(A) receptor subunit rho-2Eukaryotic translation initiation factor 2 subunit 3
go.drugbank.com/bio_entities/BE0004636TargetHumansMember of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form...
Polypeptides: Eukaryotic translation initiation factor 2 subunit 3Synonyms: Eukaryotic translation initiation factor 2 subunit gamma XSodium- and chloride-dependent GABA transporter 2
go.drugbank.com/bio_entities/BE0004776TargetHumansMediates sodium- and chloride-dependent transport of gamma-aminobutyric acid (GABA) (PubMed:17502375, PubMed:22932902). Mediates transport of beta-alanine (PubMed:17502375). Can also mediate transport of taurine and hypotaurine (By simil...
Polypeptides: Sodium- and chloride-dependent GABA transporter 2Synonyms: GAT-2