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Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541MetabolicIn the intestine, the 4-Ethylphenol produced from both tyrosine and phenylalanine is metabolized via a sulfotransferase into the uremic toxin 4-Ethylphenylsulfate. 4-ethylphenol sulfate is a uremic toxin … It has also been found to be related to cardiovascular mortality and to cause cell apoptosis.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreMetabolism and Physiological Effects of Imidazolepropionic Acid
smpdb.ca/view/SMP0126521MetabolicHistidine can be obtained from the diet from foods such as meat and dairy and other foods high in protein. ImP is a very strong basic compound (based on its pKa). … ImP is a metabolite of histidine and it is formed from histidine via a urocanate intermediate in gut microbiota by the enzyme urocanate reductase (urdA).
Drugs: HistidineMetabolism and Physiological Effects of N-Acetylphenylalanine
smpdb.ca/view/SMP0126720MetabolicAbout 85% of all human proteins and 68% of all yeast proteins are acetylated at their N-terminus. Several proteins from prokaryotes and archaea are also modified by N-terminal acetylation. … In particular, N-Acetyl-L-phenylalanine can be biosynthesized from L-phenylalanine and acetyl-CoA by the enzyme phenylalanine N-acetyltransferase.
Drugs: PhenylalanineMetabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn particular, phenol sulphate can be biosynthesized from phenol and phosphoadenosine phosphosulfate through the action of the enzyme sulfotransferase 1A1 in the liver. … Phenol sulphate can also arise from the consumption of phenol or from phenol poisoning. Phenol sulphate is produced from the conjugation of phenol with sulphate in the liver.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicTestosterone is the primary male sex hormone and anabolic steroid in males. Like other steroid hormones, testosterone is derived from cholesterol. … Androsterone has generally been considered to be an inactive metabolite of testosterone, which when conjugated by glucuronidation and sulfation allows testosterone to be removed from the body.
Drugs: Testosterone2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseA deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid. … A deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Metabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells. … Phenyl sulphate is shown to cause albuminuria and diabetic kidney disease.
Metabolism and Physiological Effects of Para-cresol
smpdb.ca/view/SMP0123214MetabolicPara-cresol(P-cresol) is a phenolic compound that is formed through gut microbial metabolism from the amino acid tyrosine which is acquired from foods that are high in protein. … Most of the p-cresol that is produced from the gut microbes then enters systemic circulation.
Metabolism and Physiological Effects of Indoxyl Sulfate
smpdb.ca/view/SMP0123237MetabolicIndoxyl sulfate is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a sulfation reaction in liver hepatic cells. … Indole that is produced from the gut microbes then enters systemic circulation.