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Potassium voltage-gated channel subfamily KQT member 2
go.drugbank.com/bio_entities/BE0000897TargetTransporterHumansPore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed:24277843, PubMed:28793216, PubMed:9836639). M-channel is composed of pore-formin...
Polypeptides: Potassium voltage-gated channel subfamily KQT member 2Synonyms: KQT-like 2G protein-activated inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0001030TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as externa...
Polypeptides: G protein-activated inward rectifier potassium channel 2Synonyms: GIRK-2, KATP-2ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
go.drugbank.com/bio_entities/BE0001241TargetHumansCatalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) (PubMed:7805847). Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from i...
Polypeptides: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2Synonyms: cADPR hydrolase 2, ADP-ribosyl cyclase 22-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
go.drugbank.com/bio_entities/BE0001617TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate
Polypeptides: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthaseFunction: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
go.drugbank.com/bio_entities/BE0001661TargetEscherichia coli (strain K12)Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseFunction: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
go.drugbank.com/bio_entities/BE0001839TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Polypeptides: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferaseFunction: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activityActin-related protein 2/3 complex subunit 1B
go.drugbank.com/bio_entities/BE0004249TargetHumansComponent of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched act...
Polypeptides: Actin-related protein 2/3 complex subunit 1BActin-related protein 2/3 complex subunit 3
go.drugbank.com/bio_entities/BE0004253TargetHumansComponent of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in th...
Polypeptides: Actin-related protein 2/3 complex subunit 3Small conductance calcium-activated potassium channel protein 2
go.drugbank.com/bio_entities/BE0004426TargetHumansSmall conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular cal...
Polypeptides: Small conductance calcium-activated potassium channel protein 2Synonyms: SKCa 2Potassium voltage-gated channel subfamily A member 2
go.drugbank.com/bio_entities/BE0004715TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firi...
Polypeptides: Potassium voltage-gated channel subfamily A member 2