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Displaying results 531 - 540 of 1186 in total
  1. Drug

    Clobazam

    go.drugbank.com/drugs/DB00349
    ApprovedIllicitInvestigational

    [A256913] Unlike older 1,4-benzodiazepines, clobazam has a better side-effects profile, particularly less sedative and amnesic effects. … [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining

    Categories: GABA-A Receptor Agonists
  2. Target

    Type-1 angiotensin II receptor

    go.drugbank.com/bio_entities/BE0000062
    TargetHumans

    Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482 … The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers

    Polypeptides: Type-1 angiotensin II receptorSynonyms: AT1 receptor, Angiotensin II type-1 receptor
  3. Target

    Peroxisome proliferator-activated receptor gamma

    go.drugbank.com/bio_entities/BE0000215
    TargetHumans

    Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism … Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression (PubMed:16150867

    Polypeptides: Peroxisome proliferator-activated receptor gammaSynonyms: Nuclear receptor subfamily 1 group C member 3
  4. Target

    Interferon alpha/beta receptor 2

    go.drugbank.com/bio_entities/BE0000385
    TargetHumans

    Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569

    Polypeptides: Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 2, Type I interferon receptor 2
  5. Target

    Glutamate receptor ionotropic, NMDA 2C

    go.drugbank.com/bio_entities/BE0000454
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Particip...

    Polypeptides: Glutamate receptor ionotropic, NMDA 2CSynonyms: N-methyl D-aspartate receptor subtype 2C, Glutamate [NMDA] receptor subunit epsilon-3
  6. Target

    Atrial natriuretic peptide receptor 1

    go.drugbank.com/bio_entities/BE0000556
    TargetHumans

    Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315).

    Polypeptides: Atrial natriuretic peptide receptor 1Synonyms: Atrial natriuretic peptide receptor type A
  7. Target

    Free fatty acid receptor 1

    go.drugbank.com/bio_entities/BE0000688
    TargetHumans

    G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. … May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity).

    Polypeptides: Free fatty acid receptor 1Synonyms: G protein-coupled receptor 40
  8. Target

    Fibroblast growth factor receptor 2

    go.drugbank.com/bio_entities/BE0000748
    TargetHumans

    Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis,

    Polypeptides: Fibroblast growth factor receptor 2Synonyms: Keratinocyte growth factor receptor
  9. Target

    Glutamate receptor ionotropic, NMDA 2A

    go.drugbank.com/bio_entities/BE0000760
    TargetHumans

    Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity)

    Polypeptides: Glutamate receptor ionotropic, NMDA 2ASynonyms: N-methyl D-aspartate receptor subtype 2A, Glutamate [NMDA] receptor subunit epsilon-1
  10. Target

    Glutamate receptor ionotropic, kainate 2

    go.drugbank.com/bio_entities/BE0000826
    TargetHumans

    Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7536611, PubMed:8730589, PubMed:14511640 … The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589

    Polypeptides: Glutamate receptor ionotropic, kainate 2Synonyms: Glutamate receptor 6, Excitatory amino acid receptor 4