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A-type voltage-gated potassium channel KCND1
go.drugbank.com/bio_entities/BE0004726TargetHumansA-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). … May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior.
Polypeptides: A-type voltage-gated potassium channel KCND1Synonyms: Shal-type potassium channel KCND1, Voltage-gated potassium channel subunit Kv4.1Calcium-activated potassium channel subunit alpha-1
go.drugbank.com/bio_entities/BE0004784TargetMousePotassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). … In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map.
Polypeptides: Calcium-activated potassium channel subunit alpha-1Synonyms: Calcium-activated potassium channel, subfamily M subunit alpha-1Sodium/potassium-transporting ATPase subunit beta-1
go.drugbank.com/bio_entities/BE0004994TransporterTargetHumansMechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520) … Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs).
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-1Synonyms: Sodium/potassium-dependent ATPase subunit beta-1Sodium/potassium-transporting ATPase subunit beta-3
go.drugbank.com/bio_entities/BE0005026TransporterTargetHumansThis is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Polypeptides: Sodium/potassium-transporting ATPase subunit beta-3Synonyms: Sodium/potassium-dependent ATPase subunit beta-3Sodium/potassium-transporting ATPase subunit alpha-2
go.drugbank.com/bio_entities/BE0005034TargetTransporterHumansThis process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function (PubMed:33880529) … It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity).
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-2Sodium/potassium-transporting ATPase subunit alpha-3
go.drugbank.com/bio_entities/BE0005047TargetTransporterHumansIn the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933 … Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed
Polypeptides: Sodium/potassium-transporting ATPase subunit alpha-3ATP-sensitive inward rectifier potassium channel 10
go.drugbank.com/bio_entities/BE0009591TargetHumansCan be blocked by extracellular barium and cesium (PubMed:8995301). … Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:8995301).
Polypeptides: ATP-sensitive inward rectifier potassium channel 10Synonyms: ATP-dependent inwardly rectifying potassium channel Kir4.1, Potassium channel, inwardly rectifying subfamily J member 10G protein-activated inward rectifier potassium channel 1
go.drugbank.com/bio_entities/BE0001028TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. … Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.
Polypeptides: G protein-activated inward rectifier potassium channel 1Synonyms: Potassium channel, inwardly rectifying subfamily J member 3Potassium voltage-gated channel subfamily KQT member 3
go.drugbank.com/bio_entities/BE0002398TargetTransporterHumansThe native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness … M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed:28793216).
Polypeptides: Potassium voltage-gated channel subfamily KQT member 3Synonyms: Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3G protein-activated inward rectifier potassium channel 3
go.drugbank.com/bio_entities/BE0005190TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. … Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.
Polypeptides: G protein-activated inward rectifier potassium channel 3Synonyms: Potassium channel, inwardly rectifying subfamily J member 9