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Displaying results 61 - 70 of 208 in total
  1. Target

    Spermidine/spermine N(1)-acetyltransferase

    go.drugbank.com/bio_entities/BE0001716
    TargetBacillus subtilis (strain 168)

    Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.

    Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1
  2. Target

    Cell growth-regulating nucleolar protein

    go.drugbank.com/bio_entities/BE0008958
    TargetMouse

    Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).

    Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264
  3. Target

    Zinc transporter ZIP5

    go.drugbank.com/bio_entities/BE0009888
    TransporterHumans

    Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine … The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509).

    Synonyms: Zrt- and Irt-like protein 5
  4. Target

    G protein-coupled receptor kinase 2

    go.drugbank.com/bio_entities/BE0000341
    TargetHumans

    Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (PubMed:21799898, PubMed:23077507). … Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378).

    Synonyms: BARK, BARK1
  5. Target

    Complement C4-B

    go.drugbank.com/bio_entities/BE0004686
    TargetHumans

    Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Basic complement C4
  6. Target

    Stabilin-2

    go.drugbank.com/bio_entities/BE0004948
    TargetHumans

    Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA).

    Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2
  7. Target

    Prolyl 3-hydroxylase 1

    go.drugbank.com/bio_entities/BE0002202
    TargetEnzymeHumans

    Has prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen

    Synonyms: Leucine- and proline-enriched proteoglycan 1
  8. Target

    Zinc transporter ZIP11

    go.drugbank.com/bio_entities/BE0009906
    TransporterHumans

    Zinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechan...

    Synonyms: Zrt- and Irt-like protein 11
  9. Target

    Protein phosphatase 1 regulatory subunit 15A

    go.drugbank.com/bio_entities/BE0011888
    TargetHumans

    Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). … Also acts a viral restriction factor by attenuating HIV-1 and influenza A virus replication (PubMed:31778897, PubMed:41747053).

    Synonyms: Growth arrest and DNA damage-inducible protein GADD34
  10. Target

    Alpha-2-macroglobulin

    go.drugbank.com/bio_entities/BE0000910
    TargetCarrierHumans

    Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase

    Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5