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Displaying results 61 - 70 of 93 in total
  1. Target

    CD40 ligand

    go.drugbank.com/bio_entities/BE0001006
    TargetHumans

    Involved in immunoglobulin class switching (By similarity)

  2. Target

    Disintegrin and metalloproteinase domain-containing protein 28

    go.drugbank.com/bio_entities/BE0003872
    TargetHumans

    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation

    Function: immunoglobulin receptor binding
  3. Target

    IgG receptor FcRn large subunit p51

    go.drugbank.com/bio_entities/BE0010182
    TargetTransporterCarrierHumans

    Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:10933786, PubMed:7964511).

  4. Target

    Myeloid cell surface antigen CD33

    go.drugbank.com/bio_entities/BE0000674
    TargetHumans

    Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (PubMed:10611343, PubMed:11320212, PubMed

  5. Target

    Mitogen-activated protein kinase kinase kinase 8

    go.drugbank.com/bio_entities/BE0010492
    TargetHumans

    Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

  6. Target

    T-lymphocyte activation antigen CD80

    go.drugbank.com/bio_entities/BE0000847
    TargetHumans

    Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:38467718).

  7. Target

    B-lymphocyte antigen CD19

    go.drugbank.com/bio_entities/BE0003496
    TargetHumans

    Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126)

  8. Target

    T-lymphocyte activation antigen CD86

    go.drugbank.com/bio_entities/BE0000846
    TargetHumans

    Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:12196291, PubMed:7694363).

  9. Target

    RecQ-like DNA helicase BLM

    go.drugbank.com/bio_entities/BE0013493
    TargetHumans

    Telomeres, immunoglobulin heavy chain switch regions and rDNA are notably G-rich; formation of G-quadruplex DNA would block DNA replication and transcription (PubMed:18426915, PubMed:9765292). … Helicase activity is higher on G-quadruplex substrates than on duplex DNA substrates (PubMed:9765292).

  10. Target

    Tyrosine-protein kinase Fgr

    go.drugbank.com/bio_entities/BE0005539
    TargetHumans

    Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B.