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Complement C5
go.drugbank.com/bio_entities/BE0000855TargetHumansPrecursor of the C5a anaphylatoxin and complement C5b components of the complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that … Activated downstream of classical, alternative, lectin and GZMK complement pathways (PubMed:12878586, PubMed:18204047, PubMed:30643019, PubMed:39914456, PubMed:39814882, PubMed:6554279)
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4Complement C3
go.drugbank.com/bio_entities/BE0003455TargetHumansPrecursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1Pregnancy zone protein
go.drugbank.com/bio_entities/BE0009089TargetHumansFollowing cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase … Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism.
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6Serine/threonine-protein kinase ATR
go.drugbank.com/bio_entities/BE0010060TargetHumansInvolved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at ' … Acts as a mechanical stress sensor at the nuclear envelope: relocalizes to the nuclear envelope in response to mechanical stress and mediates a checkpoint via phosphorylation of CHEK1 (PubMed:25083873)
Synonyms: Ataxia telangiectasia and Rad3-related proteinPotassium channel subfamily T member 1
go.drugbank.com/bio_entities/BE0015369TargetHumansContributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2Spermidine/spermine N(1)-acetyltransferase
go.drugbank.com/bio_entities/BE0001716TargetBacillus subtilis (strain 168)Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.
Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Prevents NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal (PubMed:19489080).
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Zinc transporter ZIP5
go.drugbank.com/bio_entities/BE0009888TransporterHumansThe transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). … Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine
Synonyms: Zrt- and Irt-like protein 5Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA).
Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Prolyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1