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Displaying results 751 - 760 of 1186 in total
  1. Target

    Taste receptor type 1 member 2

    go.drugbank.com/bio_entities/BE0000395
    TargetHumans

    Key component of the sweet taste receptor (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). … Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580)

    Polypeptides: Taste receptor type 1 member 2Synonyms: Sweet taste receptor T1R2, G protein-coupled receptor 71
  2. Target

    Neuronal acetylcholine receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0000850
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...

    Polypeptides: Neuronal acetylcholine receptor subunit beta-2
  3. Target

    Platelet-derived growth factor receptor alpha

    go.drugbank.com/bio_entities/BE0000852
    TargetEnzymeHumans

    Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis

    Polypeptides: Platelet-derived growth factor receptor alphaSynonyms: Alpha platelet-derived growth factor receptor, Platelet-derived growth factor receptor 2
  4. Target

    Macrophage colony-stimulating factor 1 receptor

    go.drugbank.com/bio_entities/BE0000853
    TargetHumans

    Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor … Tyrosine-protein kinase that acts as a cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells

    Polypeptides: Macrophage colony-stimulating factor 1 receptorSynonyms: CSF-1 receptor
  5. Target

    Epithelial discoidin domain-containing receptor 1

    go.drugbank.com/bio_entities/BE0001124
    TargetHumans

    Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation

    Polypeptides: Epithelial discoidin domain-containing receptor 1Synonyms: Discoidin receptor tyrosine kinase, Epithelial discoidin domain receptor 1
  6. Target

    Ferrichrome outer membrane transporter/phage receptor

    go.drugbank.com/bio_entities/BE0001326
    TargetEscherichia coli (strain K12)

    In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages

    Polypeptides: Ferrichrome outer membrane transporter/phage receptorSynonyms: Ferric hydroxamate receptor, Ferrichrome-iron receptor
  7. Target

    Neuronal acetylcholine receptor subunit alpha-7

    go.drugbank.com/bio_entities/BE0002341
    TargetHumans

    In T cells, activation induces metabotropic signaling that results in an increase of intracellular Ca2+ concentrations, independent of ionotropic receptor functions (PubMed:17709503).

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-7Synonyms: Nicotinic acetylcholine receptor subunit alpha-7
  8. Target

    Growth hormone secretagogue receptor type 1

    go.drugbank.com/bio_entities/BE0003383
    TargetHumans

    G protein-coupled receptor specific to ghrelin, an appetite-regulating peptide hormone commonly found in stomach (PubMed:35027551, PubMed:39833471).

    Polypeptides: Growth hormone secretagogue receptor type 1Synonyms: Ghrelin receptor, GH-releasing peptide receptor
  9. Target

    C-C chemokine receptor type 2

    go.drugbank.com/bio_entities/BE0003387
    TargetHumans

    Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). … Key functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855).

    Polypeptides: C-C chemokine receptor type 2Synonyms: Monocyte chemoattractant protein 1 receptor
  10. Target

    C-C chemokine receptor type 1

    go.drugbank.com/bio_entities/BE0003509
    TargetHumans

    Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:14991608).

    Polypeptides: C-C chemokine receptor type 1Synonyms: LD78 receptor, Macrophage inflammatory protein 1-alpha receptor