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Acetyl-coenzyme A synthetase 2-like, mitochondrial
go.drugbank.com/bio_entities/BE0000746TargetHumansProvides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). … Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062).
Synonyms: Acetate--CoA ligase 2, Acetyl-CoA synthetase 2Function: acetyl-CoA synthetase activityAcetyl-coenzyme A synthetase, cytoplasmic
go.drugbank.com/bio_entities/BE0000350TargetEnzymeHumansCatalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:10843999, PubMed:28003429, PubMed:28552616, PubMed:38369012, PubMed:39561764). … Catalyzes the conversion of lactate into lactoyl-CoA (PubMed:39561764). Does not catalyze the conversion of butyrate or crotonate to their corresponding acyl-CoAs (PubMed:38369012).
Synonyms: Acetate--CoA ligase, Acetyl-CoA synthetaseFunction: acetyl-CoA synthetase activityBile acid-CoA:amino acid N-acyltransferase
go.drugbank.com/bio_entities/BE0002303TargetEnzymeHumansMay also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids (PubMed:12239217, PubMed:12810727, PubMed:8034703).
Synonyms: Choloyl-CoA hydrolase, Bile acid-CoA thioesterase3-hydroxy-3-methylglutaryl-coenzyme A reductase
go.drugbank.com/bio_entities/BE0000574TargetEnzymeHumansCatalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular
Synonyms: HMG-CoA reductasePeroxisomal acyl-coenzyme A oxidase 1
go.drugbank.com/bio_entities/BE0004135TargetEnzymeHumansCatalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular
Synonyms: Palmitoyl-CoA oxidase, Straight-chain acyl-CoA oxidaseFunction: acyl-CoA oxidase activity3-hydroxy-3-methylglutaryl-coenzyme A reductase
go.drugbank.com/bio_entities/BE0001856TargetPseudomonas mevaloniiWith this enzyme mevalonate is deacetylated to HMG-CoA.
Synonyms: HMG-CoA reductaseFunction: hydroxymethylglutaryl-CoA reductase (NADH) activityCartilage oligomeric matrix protein
go.drugbank.com/bio_entities/BE0000899TargetHumansPlays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix...
Synonyms: COMPMitogen-activated protein kinase kinase kinase 8
go.drugbank.com/bio_entities/BE0010492TargetHumansRequired for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regula...
Synonyms: COT, Proto-oncogene c-CotCarminomycin 4-O-methyltransferase DnrK
go.drugbank.com/bio_entities/BE0001712TargetStreptomyces peucetiusInvolved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In...
Synonyms: COMTLong-chain fatty acid transport protein 2
go.drugbank.com/bio_entities/BE0009868EnzymeHumansAlso functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells
Synonyms: THCA-CoA ligase, Arachidonate--CoA ligaseFunction: arachidonate-CoA ligase activity