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Displaying results 71 - 80 of 124 in total
  1. Pathway

    Naltrexone Opioid Antagonist Action Pathway

    smpdb.ca/view/SMP0125274
    Drug action

    Naltrexone also prevents the gamma subunit of the mu opioid receptor from inhibiting the N-type calcium channels on the neuron. This allows calcium to enter the neuron and depolarize.

    Drugs: ATP · Naltrexone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  2. Pathway

    Tramadol Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0125025
    Drug action

    Tramadol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Tramadol binds to mu opioid receptors, stimulating the exchange of GTP for...

    Drugs: ATP · Tramadol · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  3. Pathway

    Levorphanol Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0125026
    Drug action

    Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, howev...

    Drugs: ATP · Levorphanol · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  4. Pathway

    Difelikefalin Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0126764
    Drug action

    Difelikefalin is a kappa opioid receptor agonist used in the treatment of moderate-to-severe pruritus (itchy skin) associated with chronic kidney disease in patients undergoing hemodialysis. It is administered via intravenous injection a...

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid · Pyrophosphoric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  5. Pathway

    Caffeine Nervous Action Pathway

    smpdb.ca/view/SMP0125297
    Drug action

    Caffeine is a central nervous system stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. Consistent intake of caffeine increases the population of adenosine receptors, which can poten...

    Drugs: Pyridoxal phosphate · Glutamic acid · Caffeine · Norepinephrine · Adenosine · Calcium +1 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit alpha-1
  6. Pathway

    Meperidine opioid agonist Action Pathway

    smpdb.ca/view/SMP0125199
    Drug action

    Meperidine is a narcotic analgesic opioid that is used for moderate to severe pain. It is less effetive than Morphine, but also has shorter side-effects. Mepereidine is effective locally or in the central nervous system in the brain and ...

    Drugs: ATP · Meperidine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  7. Pathway

    Remifentanil Opioid Analgesic Action Pathway

    smpdb.ca/view/SMP0126828
    Drug action

    Remifentanil is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic...

    Drugs: ATP · Remifentanil · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  8. Pathway

    Alfentanil Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0124996
    Drug action

    Alfentanil is used to induce and maintain anesthesia, as well as an analgesic. Alfentanil is a short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of conscious...

    Drugs: ATP · Alfentanil · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  9. Pathway

    Dezocine Mu Opioid Agonism Action Pathway

    smpdb.ca/view/SMP0126631
    Drug action

    Through the gamma subunit of the mu-opioid receptor the N-type calcium channels on the neuron is inhibited, further causing hyperpolarization.

    Drugs: ATP · Dezocine · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2
  10. Pathway

    Hydrocodone Opioid Agonist Action Pathway

    smpdb.ca/view/SMP0125016
    Drug action

    Hydrocodone is an opioid agonist used as an analgesic and antitussive agent. It is a synthetic opioid derivative of codeine. Hydrocodone is indicated for the management of acute pain, sometimes in combination with acetaminophen or ibupro...

    Drugs: ATP · Hydrocodone · Calcium · Magnesium cation · Cyclic adenosine monophosphate · gamma-Aminobutyric acid +2 more
    Enzymes: Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid type B receptor subunit 2