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Voltage-dependent L-type calcium channel subunit alpha-1S
go.drugbank.com/bio_entities/BE0002355TargetHumansreticulum and ultimately results in muscle contraction. … Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic
Polypeptides: Voltage-dependent L-type calcium channel subunit alpha-1SSynonyms: Voltage-gated calcium channel subunit alpha Cav1.1, Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscleVoltage-dependent L-type calcium channel subunit alpha-1D
go.drugbank.com/bio_entities/BE0002359TargetHumansVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone … They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines
Polypeptides: Voltage-dependent L-type calcium channel subunit alpha-1DSynonyms: Voltage-gated calcium channel subunit alpha Cav1.3, Calcium channel, L type, alpha-1 polypeptide, isoform 2Calcium/calmodulin-dependent protein kinase type II subunit beta
go.drugbank.com/bio_entities/BE0003792TargetHumansCalcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity … potentiation (LTP) and hippocampus-dependent learning.
Polypeptides: Calcium/calmodulin-dependent protein kinase type II subunit betaDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
go.drugbank.com/bio_entities/BE0001300TargetHumansMay act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K
Polypeptides: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositideVoltage-dependent T-type calcium channel subunit alpha-1I
go.drugbank.com/bio_entities/BE0000012TargetTransporterHumansThis channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. … Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone
Polypeptides: Voltage-dependent T-type calcium channel subunit alpha-1ISynonyms: Voltage-gated calcium channel subunit alpha Cav3.3Voltage-dependent L-type calcium channel subunit beta-1
go.drugbank.com/bio_entities/BE0000303TargetHumansRegulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847). … Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:15615847, PubMed:8107964).
Polypeptides: Voltage-dependent L-type calcium channel subunit beta-1Synonyms: Calcium channel voltage-dependent subunit beta 1Voltage-dependent T-type calcium channel subunit alpha-1H
go.drugbank.com/bio_entities/BE0000864TargetHumansT-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). … Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group.
Polypeptides: Voltage-dependent T-type calcium channel subunit alpha-1HSynonyms: Voltage-gated calcium channel subunit alpha Cav3.2, Low-voltage-activated calcium channel alpha1 3.2 subunitVoltage-dependent L-type calcium channel subunit beta-4
go.drugbank.com/bio_entities/BE0002356TargetHumansThe beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation … , modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting
Polypeptides: Voltage-dependent L-type calcium channel subunit beta-4Synonyms: Calcium channel voltage-dependent subunit beta 4Voltage-dependent calcium channel subunit alpha-2/delta-2
go.drugbank.com/bio_entities/BE0002396TargetHumansThe alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. … Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G) (PubMed:15111129, PubMed:23339110).
Polypeptides: Voltage-dependent calcium channel subunit alpha-2/delta-2Synonyms: Voltage-gated calcium channel subunit alpha-2/delta-2Calcium/calmodulin-dependent protein kinase type II subunit delta
go.drugbank.com/bio_entities/BE0004108TargetHumansCalcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins … In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159
Polypeptides: Calcium/calmodulin-dependent protein kinase type II subunit delta