Search
ADP-L-glycero-D-manno-heptose-6-epimerase
go.drugbank.com/bio_entities/BE0001296TargetEscherichia coli (strain K12)Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Polypeptides: ADP-L-glycero-D-manno-heptose-6-epimeraseSynonyms: ADP-L-glycero-beta-D-manno-heptose-6-epimerasePregnancy zone protein
go.drugbank.com/bio_entities/BE0009089TargetHumansFollowing cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6Serine/threonine-protein kinase ATR
go.drugbank.com/bio_entities/BE0010060TargetHumansPhosphorylates BRCA1, CHEK1, MCM2, RAD17, RBBP8, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis (PubMed:11114888, PubMed … Involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability and catalyzing phosphorylation of LMNA at '
Synonyms: Ataxia telangiectasia and Rad3-related proteinPotassium channel subfamily T member 1
go.drugbank.com/bio_entities/BE0015369TargetHumansContributes to synaptic development and plasticity (By similarity) … Acts as an important mediator of neuronal membrane excitability (PubMed:37494189). Contributes to the delayed outward currents (By similarity).
Synonyms: Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2Spermidine/spermine N(1)-acetyltransferase
go.drugbank.com/bio_entities/BE0001716TargetBacillus subtilis (strain 168)Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and releases both CoA and the acetylated product. … Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase.
Synonyms: Protease synthase and sporulation negative regulatory protein PAI 1Cell growth-regulating nucleolar protein
go.drugbank.com/bio_entities/BE0008958TargetMousePlays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). … Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (By similarity).
Synonyms: Protein expressed in male leptotene and zygotene spermatocytes 264Zinc transporter ZIP5
go.drugbank.com/bio_entities/BE0009888TransporterHumansThe transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). … Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine
Synonyms: Zrt- and Irt-like protein 5Stabilin-2
go.drugbank.com/bio_entities/BE0004948TargetHumansBinds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. … The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS
Synonyms: FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2Prolyl 3-hydroxylase 1
go.drugbank.com/bio_entities/BE0002202TargetEnzymeHumansHas prolyl 3-hydroxylase activity and catalyzes the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in pro-collagen chains, a critical step for the formation of mature collagen
Synonyms: Leucine- and proline-enriched proteoglycan 1Zinc transporter ZIP11
go.drugbank.com/bio_entities/BE0009906TransporterHumansZinc importer that regulates cytosolic zinc concentrations either via zinc influx from the extracellular compartment or efflux from intracellular organelles such as Golgi apparatus. May transport copper ions as well. The transport mechan...
Synonyms: Zrt- and Irt-like protein 11