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Displaying results 71 - 80 of 134094 in total
  1. Pathway

    Metabolism and Phsyiological Effects of Asymmetric dimethylarginine (ADMA)

    smpdb.ca/view/SMP0124747
    Metabolic

    L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to ADMA via the enzyme protein arginine methyltransferase-1. ADMA inhibits nitric oxide synthase, preventing the formation of nitric oxide.

    Drugs: Ademetionine · Arginine
  2. Pathway

    Metabolism and Physiological Effects of Symmetric dimethylarginine (SDMA)

    smpdb.ca/view/SMP0124764
    Metabolic

    L-arginine is obtained from protein-rich foods like red meat, poultry, dairy and eggs. It is absorbed in the intestine to the blood. … It enters cells in the body and is metabolized to SDMA via the enzyme protein arginine methyltransferase-5 or protein arginine methyltransferase-7.

    Drugs: Ademetionine · Arginine · Symmetric dimethylarginine
  3. Pathway

    Metabolism and Physiological Effects of β-Hydroxybutyric acid

    smpdb.ca/view/SMP0126987
    Metabolic

    Glucose is metabolized into pyruvate through glycolysis in the cytoplasm, and pyruvate is completely oxidized to generate ATP through the TCA cycle and oxidative phosphorylation in the mitochondria. … Upon entering the tissues, beta-hydroxybutyrate is converted by D-β-hydroxybutyrate dehydrogenase back to acetoacetate along with a proton and a molecule of NADH, the latter of which goes on to power the

    Drugs: NADH · Acetoacetic acid
  4. Pathway

    Intracellular Signalling Through Adenosine Receptor A2b and Adenosine

    smpdb.ca/view/SMP0000321
    Signaling

    down stream effectors that lead to a specific cellular response. … Adenosine is thought to play a role in the pathophysiology of asthma. Stimulation of A2B can induce production of interleukin-8 mast cells.

    Drugs: ATP · Adenosine · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Pyrophosphoric acid
  5. Pathway

    Metabolism and Physiological Effects of 2-Aminobenzoic acid

    smpdb.ca/view/SMP0126869
    Disease

    Chronic exposure of uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. … Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss.

    Drugs: Tryptophan · Alanine · Formic acid · Kynurenine · Mesoheme · Anthranilic acid +1 more
    Enzymes: Neutral and basic amino acid transport protein rBAT
  6. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyphenylacetic acid

    smpdb.ca/view/SMP0126879
    Metabolic

    , and C. propionicum. l-tyrosine, derived from diet and endogenous proteins and peptides, can be converted to phenol and 4-hydroxyphenylpyruvate. … To a small extent, 4-hydroxyphenylpyruvate and ammonia can also be formed by the enzyme phenylalanine dehydrogenase (EC 1.4.1.20.) from l-tyrosine.

    Drugs: Pyridoxal phosphate · Tyrosine · Glutamic acid · P-Cresol · Oxogluric acid · 4-Hydroxyphenylpyruvic acid
  7. Pathway

    Intracellular Signalling Through PGD2 receptor and Prostaglandin D2

    smpdb.ca/view/SMP0000343
    Signaling

    effectors that lead to a specific cellular response. … The PGD receptor activates G(s) proteins which lead to the activation of adenylyl cyclase which produces the secondary messenger cAMP. cAMP activates PKA (protein kinase A) which phosphorylates downstream

    Drugs: ATP · Magnesium cation · Prostaglandin D2 · Cyclic adenosine monophosphate · Pyrophosphoric acid
  8. Pathway

    Metabolism and Physiological Effects of Indole Acetic Acid

    smpdb.ca/view/SMP0123235
    Metabolic

    Indole acetic acid is shown to cause inflammation and disrupt the electron transport chain and oxidative phosphorylation causing muscle atrophy. … After being transported into gut microbes, tryptophan undergoes a reaction with the enzymes tryptophan monooxygenase and indole-3-acetamide hydrolase to form indole acetic acid.

    Drugs: Tryptophan
  9. Pathway

    Metabolism and Physiological Effects of Para-cresyl glucuronide

    smpdb.ca/view/SMP0123299
    Metabolic

    After being transported into gut microbes, tyrosine undergoes reactions with the enzymes tyrosine transaminase, 4-hydroxyphenylpyruvate oxidase and 4-hydroxylphenylacetate decarboxylase to form para-cresol … Most of the p-cresol that is produced from the gut microbes then enters systemic circulation and is converted into P-cresyl sulphate by the liver.

    Drugs: Tyrosine · P-Cresol · 4-Hydroxyphenylpyruvic acid
  10. Pathway

    Metabolism and Physiological Effects of 4-Hydroxyhippuric Acid

    smpdb.ca/view/SMP0125537
    Metabolic

    ; nuts such as​ cashews, almonds, pistachios; and dairy products such as yogurt, milk, and cheese. … Hippuric acid leaves the mitochondria and is metabolized in the membrane of the endoplasmic reticulum by the enzyme cytochrome P450 1A2 to produce 4-Hydroxyhippuric. 4-Hydroxyhippuric is transported into

    Drugs: ATP · Calcium · Mesoheme · Benzoic acid · Pyrophosphoric acid