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Tyrosine 3-monooxygenase
go.drugbank.com/bio_entities/BE0000614TargetHumansCatalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert ...
Polypeptides: Tyrosine 3-monooxygenaseSynonyms: Tyrosine 3-hydroxylaseGlutathione peroxidase 3
go.drugbank.com/bio_entities/BE0000821TargetHumansProtects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
Polypeptides: Glutathione peroxidase 3Synonyms: GPx-3, GSHPx-3Integrin beta-3
go.drugbank.com/bio_entities/BE0001155TargetCarrierTransporterHumansIntegrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand … Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.
Polypeptides: Integrin beta-3Chloramphenicol acetyltransferase 3
go.drugbank.com/bio_entities/BE0001542TargetEnzymeEscherichia coliThis enzyme is an effector of chloramphenicol resistance in bacteria.
Polypeptides: Chloramphenicol acetyltransferase 33-isopropylmalate dehydrogenase
go.drugbank.com/bio_entities/BE0001699TargetThiobacillus ferrooxidansCatalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Polypeptides: 3-isopropylmalate dehydrogenaseSynonyms: 3-IPM-DH3-dehydroquinate dehydratase
go.drugbank.com/bio_entities/BE0001819TargetSalmonella typhiCatalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. … The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsilon-amino group of Lys-170 at the active site.
Polypeptides: 3-dehydroquinate dehydrataseSynonyms: 3-dehydroquinaseSerine palmitoyltransferase 3
go.drugbank.com/bio_entities/BE0002172TargetHumansComponent of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form lon...
Polypeptides: Serine palmitoyltransferase 3Synonyms: LCB 3, SPT 33-mercaptopyruvate sulfurtransferase
go.drugbank.com/bio_entities/BE0002824TargetEscherichia coli (strain K12)Catalyzes the transfer of sulfur from 3-mercaptopyruvate to a thiol-containing acceptor to form an intramolecular disulfide releasing hydrogen sulfide and pyruvate (Probable).
Polypeptides: 3-mercaptopyruvate sulfurtransferaseFunction: 3-mercaptopyruvate sulfurtransferase activityRyanodine receptor 3
go.drugbank.com/bio_entities/BE0005296TransporterTargetHumansMay regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. … Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction (PubMed
Polypeptides: Ryanodine receptor 3Synonyms: RYR-3, Type 3 ryanodine receptorP2X purinoceptor 3
go.drugbank.com/bio_entities/BE0009818TargetHumansExtracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:27626375, PubMed:29674445, PubMed:31232692). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nocicepti...
Polypeptides: P2X purinoceptor 3