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Lovastatin
go.drugbank.com/drugs/DB00227ApprovedInvestigationalwere found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while lovastatin has been found to have an average decrease in LDL-C of 25-40%. … [A181084] Elevated cholesterol levels, and in particular, elevated low-density lipoprotein (LDL) levels, are an important risk factor for the development of CVD.
Categories: lovastatin and nicotinic acidProducts: LOVAHEXAL 10MG TABL, LOVABETA 10MG TABLETTENCarbimazole
go.drugbank.com/drugs/DB00389ApprovedAn imidazole antithyroid agent. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity.
Categories: Sex Hormones and Insulins, Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: CARBIMAZOL 10MG HENNING, CARBIMAZOL 10MG HEXALNeostigmine
go.drugbank.com/drugs/DB01400ApprovedInvestigationalVet approvedA cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine.
Categories: Antiglaucoma Preparations and MioticsSynonyms: 3-Trimethylammoniumphenyl N,N-dimethylcarbamateFerrous ascorbate
go.drugbank.com/drugs/DB14490ApprovedWithdrawnCategories: Compounds used in a research, industrial, or household setting, Diet, Food, and NutritionProducts: Ascofer Cap 275mgApoptotic DNA Fragmentation and Tissue Homeostasis
smpdb.ca/view/SMP0063772SignalingICAD and CAD exist in the nucleus in normal cells and is a major endonuclease in apoptosis. Its activation is normally caspase dependent. … EndoG resides in mitochondria in normal cells and travels to the nucleus, where it fragments chromosomal DNA upon activation of apoptosis.
Drugs: ZincEnzymes: CAD proteinMetabolism and Physiological Effects of Creatinine
smpdb.ca/view/SMP0123283MetabolicCreatinine is a low-molecular-weight uremic solute and breakdown product of creatine phosphate in muscle, often used as a clinical marker of renal function (altered serum creatinine clearance levels can … If not cleared, it can reduce cardiomyocyte contractility and weaken cardiac efficiency, leading to systolic dysfunction and heart failure.
Metabolism and Physiological Effects of Xanthine
smpdb.ca/view/SMP0124865MetabolicPurines can be made endogenously in the body or can be obtained exogenously from foods such as red meat. The purines are guanine and adenine. These undergo metabolism in the liver to form xanthine. … Xanthine then enters the blood where it can have detrimental effects on other organs such as the kidney (causing renal failure) and the blood vessel (causing endothelial dysfunction).
Metabolism and Physiological Effects of Kynurenine
smpdb.ca/view/SMP0125524DiseaseIn addition to increased kynurenine production via IDO mediated synthesis, hyopalbuminemia can also lead to the release of bound kynurenine (and other immunosuppressive LysoPCs) into the bloodstream to … In the blood it travels to the liver and is transported into a hepatocyte by an amino acid transporter.
Enzymes: Neutral and basic amino acid transport protein rBATMetabolism and Physiological Effects of Isovalerylglycine
smpdb.ca/view/SMP0126748MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … IVA (OMIM/ McKusick 243500) is an autosomal recessive disorder caused by mutations in the isovaleryl-CoA dehydrogenase (EC 1.3.99.10) gene.
Metabolism and Physiological Effects of Tiglylglycine
smpdb.ca/view/SMP0126840MetabolicIn certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. … This is then converted to tiglyl-CoA by SBCAD which can then be made into tiglylglycine via glycine N-acyltransferase.