Search
Metabolism and Physiological Effects of Para-cresyl glucuronide
smpdb.ca/view/SMP0123299MetabolicMost of the p-cresol that is produced from the gut microbes then enters systemic circulation and is converted into P-cresyl sulphate by the liver. … Para-cresyl glucuronide (P-cresyl glucuronide) is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of p-Cresol sulphate
smpdb.ca/view/SMP0126850MetabolicUremic toxins include other low-molecular-weight compounds such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and asymmetric dimethylarginine. … The reversible reaction of l-tyrosine with 2-oxoglutarate in 4-hydroxyphenylpyruvate and L-glutamate is catalysed by tyrosine transaminase (EC 2.6.1.5.) or by aromatic-amino-acid transaminase (EC 2.6.1.57
Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
smpdb.ca/view/SMP0000309SignalingThe 5-HT4 receptor is primarily found in the CNS, GI tract, and PNS. … Atrial heart receptors produce positive inotropy and tachycardia that can precipitate arrhythmias.
Enzymes: cAMP-dependent protein kinase catalytic subunit betaExcitatory Neural Signalling Through 5-HTR 7 and Serotonin
smpdb.ca/view/SMP0000311SignalingThe 5-HT7 receptor is primarily found in the CNS, GI tract, and blood vessels. It is involved in thermoregulation, circadian rhythm, learning and memory, and sleep.
Enzymes: cAMP-dependent protein kinase catalytic subunit betaMetabolism and Physiological Effects of N-Formyl-L-Methionine
smpdb.ca/view/SMP0126765Metabolic) and formyl peptide receptor 2 (FPR2) G protein coupled receptors (see also formyl peptide receptor 3). … It is a proteinogenic amino acid, a N-formyl amino acid and a L-methionine derivative. It is a conjugate acid of a N-formyl-L-methioninate.
Metabolism and Physiological Effects of N-Acetyl-1-Methylhistidine
smpdb.ca/view/SMP0126802MetabolicHigher circulating levels of five of these N-acetylated amino acids, namely, N-δ-acetylornithine, N-acetyl-1-methylhistidine, N-acetyl-3-methylhistidine, N-acetylhistidine, and N2,N5-diacetylornithine, … The NAT8 gene has been associated with 14 N-acetylated amino acids, including N-Acetyl-3-methylhistidine.
Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
smpdb.ca/view/SMP0000312SignalingThe 5-HT6 receptor is primarily expressed in the brain and is involved in glutamatergic and cholinergic neuronal activity.
Enzymes: cAMP-dependent protein kinase catalytic subunit betaMetabolism and Physiological Effects of Trimethylamine N-oxide (TMAO)
smpdb.ca/view/SMP0123192MetabolicThis trimethylamine then enters a liver hepatocyte through portal circulation and gets metabolized by FMO3 to form TMAO. … First choline obtained from choline rich foods such as eggs or meat enter the gut and get metabolized to trimethylamine by gut microbes.
Enzymes: Dimethylaniline monooxygenase [N-oxide-forming] 3Metabolism and Physiological Effects of N-Acetyl-L-Alanine
smpdb.ca/view/SMP0126554MetabolicN-acyl-alpha amino acids are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. … Individuals with aminoacylase I deficiency will experience convulsions, hearing loss and difficulty feeding. Many N-acetylamino acids, including N-acetylalanine, are classified as uremic toxins.
Drugs: AlanineIntracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells.
Enzymes: Follitropin subunit beta, cAMP-dependent protein kinase catalytic subunit beta